Professor, Department of Psychiatry, University of Florida College of Medicine, Gainesville, FL
Department of Psychiatry
University of Florida College of Medicine
PO Box 100256
Gainesville, FL 32610-0256
Phone: 294-5203 (office), 294-5047 (lab)
B.A. Psychology, Yale University
Ph.D. Biological Sciences, Department of Neurobiology and Behavior, University of California, Irvine
Postdoctoral Fellowship: Psychological and Brain Sciences, Johns Hopkins University, Baltimore, Maryland
Current Research Focus
Much of the research in our laboratory concerns interactions between cognition, motivation, and addiction. In some of our work, we investigate how acute and chronic exposure to drugs of abuse affects cognitive and motivational outcomes, with a particular focus on risky and impulsive decision-making processes. In other work, we investigate the neural mechanisms of such decision-making processes, and how individual differences in decision-making predict propensity for future drug use. Our laboratory uses behavioral, pharmacological, biochemical, and electrophysiological approaches in rodent models to identify mechanisms that mediate relationships between decision-making and drug use, with the goal of identifying therapeutic targets for both disordered decision-making and addiction. In addition, we collaborate with other laboratories on projects concerning the behavioral and neural basis of age-related cognitive impairments.
Outside of the laboratory, I teach courses on the neurobiology of addiction and other psychiatric disorders, and I serve on the editorial boards of several professional journals.
Simon, N. W., Gilbert, R. J., Mayse, J. D., Bizon, J. L., & Setlow, B. (2009). Balancing risk and reward: A rat model of risky decision-making. Neuropsychopharmacology. 34, 2208-2217.
Mitchell, M. R., Vokes, C. M., Blankenship, A. L., Simon, N. W., & Setlow, B. (2011). Effects of acute administration of nicotine, amphetamine, diazepam, morphine, and ethanol on risky decision-making in rats. Psychopharmacology. 218, 703-712.
Simon N. W., Montgomery, K. S., Beas, B. S., Mitchell, M. R., LaSarge, C. L., Mendez, I. A., Bañeulos, C., Vokes, C. M., Taylor, A. B., Haberman, R. P., Bizon, J. L., & Setlow, B. (2011). Dopaminergic modulation of risky decision-making. The Journal of Neuroscience. 31, 17460-17470.
Mendez, I. A., Gilbert, R. J., Bizon, J. L., & Setlow, B. (2012). Effects of acute administration of nicotinic and muscarinic cholinergic agonists and antagonists on performance in different cost-benefit decision making tasks in rats. Psychopharmacology. 224, 489-499.
Simon N. W., Beas, B. S., Montgomery, K. S., Haberman, R. P., Bizon, J. L., & Setlow, B. (2013). Prefrontal cortical-striatal dopamine receptor mRNA expression predicts distinct forms of impulsivity. European Journal of Neuroscience. 37, 1779-1788.
Beas, B. S., Setlow, B., & Bizon, J. L. (2013). Distinct manifestations of executive dysfunction in aged rats. Neurobiology of Aging. 34, 2164-2174.
Mitchell, M. R., Weiss, V. G., Beas, B. S., Morgan, D., Bizon, J. L., & Setlow, B. (2014). Adolescent risk taking, cocaine self-administration, and striatal dopamine signaling. Neuropsychopharmacology. 39, 955-962.
Bañuelos, C., Beas, B. S., McQuail, J. A., Gilbert, R. J., Frazier, C. J., Setlow, B., & Bizon, J. L. (2014). Prefrontal cortical GABAergic dysfunction contributes to age-related working memory impairment. The Journal of Neuroscience. 34, 3457-3466.
Orsini, C. A., Ginton, G., Shimp, K. G., Avena, N. M., Gold, M. S., & Setlow, B. (2014). Food consumption and weight gain after cessation of chronic amphetamine administration. Appetite.78, 76-80.
Mitchell, M. R., Weiss, V. G., Ouimet, D. J., Fuchs, R. A., Morgan, D. & Setlow, B. (2014). Intake-dependent effects of cocaine self-administration on impulsive choice in a delay discounting task. Behavioral Neuroscience. 128, 419-429.
Orsini, C. A., Trotta, R., Bizon, J. L., & Setlow, B. (2015) Dissociable roles for the basolateral amygdala and orbitofrontal cortex in decision-making under risk of punishment. The Journal of Neuroscience.35, 1368-1379.