Adriaan Bruijnzeel, PhD
Professor, Department of Psychiatry
University of Florida College of Medicine, Gainesville, FL
Department of Psychiatry
University of Florida College of Medicine
McKnight Brain Institute
PO Box 100256
Gainesville, FL 32610-0256
MSc, Animal Science, Wageningen University, Wageningen, The Netherlands
PhD Neuropharmacology, Utrecht University, Utrecht, The Netherlands
Postdoctoral Fellowship: Neuropharmacology, The Scripps Research Institute, San Diego, California
Development of novel treatments for drug addiction.
Current Research Focus
Drug addiction is a chronic disorder that is characterized by compulsive drug taking and relapse after periods of abstinence. The research in our laboratory focuses on the development of non-addictive treatments for nicotine, alcohol, and opioid addiction. We use animal models to study the neuronal substrates that mediate the negative mood state and anxiety-like behavior associated with drug withdrawal. The negative mood state associated with drug withdrawal is investigated with the intracranial self-stimulation procedure and anxiety-like behavior is investigated with the elevated plus maze test and other anxiety tests. In addition, we study drug self-administration and stress, drug, and cue-induced reinstatement of extinguished drug seeking behavior. Our research group has shown that corticotropin-releasing factor (CRF) mediates the negative mood state associated with nicotine and alcohol withdrawal and plays a critical role in stress-induced relapse of extinguished nicotine-seeking behavior. These studies may lead to the development of treatments that decrease drug abuse in humans and prevent relapse after a period of abstinence.
Bruijnzeel A.W., Gold M.S. (2005) The role of corticotropin-releasing factor in cannabis, nicotine and alcohol dependence. Brain Research Reviews, 49, 505-528.
Bruijnzeel A.W., Prado M., Isaac S., (2009) Blockade of CRF1 receptors prevents nicotine withdrawal-induced anhedonia and stress-induced relapse. Biological Psychiatry, 66, 110-117.
Gold MS, Kobeissy FH, Wang KK, Merlo LJ, Bruijnzeel A.W., Krasnova IN, Cadet JL. (2009). Methamphetamine- and trauma-induced brain injuries: comparative cellular and molecular neurobiological substrates. Biol Psychiatry. 66:118-27.
Rylkova D., Shah H.P., Small E., Bruijnzeel A.W. (2009) Deficit in brain reward function and acute and protracted anxiety-like behavior after discontinuation of a chronic alcohol liquid diet in rats. Psychopharmacology, 203, 629-640.
Bruijnzeel A.W., Small E, Pasek T.M., Yamada H. (2010) Corticotropin-releasing factor mediates the dysphoria-like state associated with alcohol withdrawal in rats. Behavioural Brain Research, 210:288-291.