Adriaan W Bruijnzeel

Adriaan W Bruijnzeel, Ph.D.

Professor

Department: MD-PSYCHIATRY
Business Phone: (352) 294-4931
Business Email: awbruijn@ufl.edu

About Adriaan W Bruijnzeel

Dr. Bruijnzeel joined the Department of Psychiatry of the College of Medicine at the University of Florida in 2004. He completed his doctorate in Neuropharmacology at Utrecht University in the Netherlands in 2001 and then came to the United States for a post-doctorate fellowship at the Scripps Research Institute, in San Diego, California. While at the Scripps Institute he studied the neuroadaptations underlying nicotine dependence. His work was funded by the Tobacco-Related Disease Research Program of the State of California.

Accomplishments

Educational Development Certificate
2017 · UF College of Medicine, Office of Faculty Affairs & Professional Development
Educator Award
2017 · UF Health Science Center
Exemplary Teacher Award
2015 · University of Florida, College of Medicine
Exemplary Teacher Award
2011 · University of Florida, College of Medicine
Distinguished Mentor Award
2009 · Howard Hughes Medical Institute Science for Life
Outstanding Research Mentor
2007-2008 · Ronald E. McNair Post Baccalaureate Achievement Program
Postdoctoral Fellowship Award
2002 · Tobacco-Related Disease Research Program of the State of California

Publications

2021
Adolescent nicotine treatment causes robust locomotor sensitization during adolescence but impedes the spontaneous acquisition of nicotine intake in adult female Wistar rats.
Pharmacology, biochemistry, and behavior. 207 [DOI] 10.1016/j.pbb.2021.173224. [PMID] 34197844.
2021
Effects of repeated adolescent exposure to cannabis smoke on cognitive outcomes in adulthood.
Journal of psychopharmacology (Oxford, England). 35(7):848-863 [DOI] 10.1177/0269881120965931. [PMID] 33295231.
2021
Rewarding effects of nicotine self-administration increase over time in male and female rats.
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. [DOI] 10.1093/ntr/ntab097. [PMID] 33987656.
2021
Rodent models for nicotine withdrawal.
Journal of psychopharmacology (Oxford, England). [DOI] 10.1177/02698811211005629. [PMID] 33888006.
2021
Sex differences in the elevated plus-maze test and large open field test in adult Wistar rats.
Pharmacology, biochemistry, and behavior. 204 [DOI] 10.1016/j.pbb.2021.173168. [PMID] 33684454.
2021
Tobacco smoke exposure enhances reward sensitivity in male and female rats.
Psychopharmacology. 238(3):845-855 [DOI] 10.1007/s00213-020-05736-0. [PMID] 33410984.
2020
Adolescent nicotine and tobacco smoke exposure enhances nicotine self-administration in female rats.
Neuropharmacology. 176 [DOI] 10.1016/j.neuropharm.2020.108243. [PMID] 32702403.
2020
Evaluation of Sex Differences in the Elasticity of Demand for Nicotine and Food in Rats.
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. 22(6):925-934 [DOI] 10.1093/ntr/ntz171. [PMID] 31603225.
2020
Evaluation of the rewarding effects of mitragynine and 7-hydroxymitragynine in an intracranial self-stimulation procedure in male and female rats.
Drug and alcohol dependence. 215 [DOI] 10.1016/j.drugalcdep.2020.108235. [PMID] 32889450.
2020
Exposure to smoke from high- but not low-nicotine cigarettes leads to signs of dependence in male rats and potentiates the effects of nicotine in female rats.
Pharmacology, biochemistry, and behavior. 196 [DOI] 10.1016/j.pbb.2020.172998. [PMID] 32681850.
2020
Overexpression of corticotropin-releasing factor in the nucleus accumbens enhances the reinforcing effects of nicotine in intact female versus male and ovariectomized female rats.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 45(2):394-403 [DOI] 10.1038/s41386-019-0543-0. [PMID] 31614362.
2020
Relationship Between Nicotine Intake and Reward Function in Rats With Intermittent Short Versus Long Access to Nicotine.
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. 22(2):213-223 [DOI] 10.1093/ntr/ntz052. [PMID] 30958557.
2020
Rewarding Effects of Nicotine in Adolescent and Adult Male and Female Rats as Measured Using Intracranial Self-stimulation.
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. 22(2):172-179 [DOI] 10.1093/ntr/nty249. [PMID] 30452710.
2020
Shifting Frontiers in Basic Research on Nicotine and Tobacco Products.
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. 22(2):145-146 [DOI] 10.1093/ntr/ntz190. [PMID] 31566234.
2019
Effects in rats of adolescent exposure to cannabis smoke or THC on emotional behavior and cognitive function in adulthood.
Psychopharmacology. 236(9):2773-2784 [DOI] 10.1007/s00213-019-05255-7. [PMID] 31044291.
2019
Enhancing effects of acute exposure to cannabis smoke on working memory performance.
Neurobiology of learning and memory. 157:151-162 [DOI] 10.1016/j.nlm.2018.12.001. [PMID] 30521850.
2019
Pharmacokinetic and Pharmacodynamic Characterization of Tetrahydrocannabinol-Induced Cannabinoid Dependence After Chronic Passive Cannabis Smoke Exposure in Rats.
Cannabis and cannabinoid research. 4(4):240-254 [DOI] 10.1089/can.2019.0049. [PMID] 32042924.
2019
Recent Updates in Animal Models of Nicotine Withdrawal: Intracranial Self-Stimulation and Somatic Signs.
Methods in molecular biology (Clifton, N.J.). 2011:253-265 [DOI] 10.1007/978-1-4939-9554-7_14. [PMID] 31273703.
2019
Sex differences in the reward deficit and somatic signs associated with precipitated nicotine withdrawal in rats.
Neuropharmacology. 160 [DOI] 10.1016/j.neuropharm.2019.107756. [PMID] 31487496.
2018
Functional connectivity, behavioral and dopaminergic alterations 24 hours following acute exposure to synthetic bath salt drug methylenedioxypyrovalerone.
Neuropharmacology. 137:178-193 [DOI] 10.1016/j.neuropharm.2018.04.031. [PMID] 29729891.
2018
Self-administration of the synthetic cathinone MDPV enhances reward function via a nicotinic receptor dependent mechanism.
Neuropharmacology. 137:286-296 [DOI] 10.1016/j.neuropharm.2018.05.008. [PMID] 29778945.
2018
Simultaneous quantification of cannabinoids tetrahydrocannabinol, cannabidiol and CB1 receptor antagonist in rat plasma: An application to characterize pharmacokinetics after passive cannabis smoke inhalation and co-administration of rimonabant.
Journal of pharmaceutical and biomedical analysis. 160:119-125 [DOI] 10.1016/j.jpba.2018.07.004. [PMID] 30077950.
2018
Video-assisted topographical measurement of cigarette smoking: Exploration of an objective approach to evaluate nicotine dependence.
Tobacco prevention & cessation. 4 [DOI] 10.18332/tpc/90821. [PMID] 32411847.
2017
Effect of Second-Hand Tobacco Smoke on the Nitration of Brain Proteins: A Systems Biology and Bioinformatics Approach.
Methods in molecular biology (Clifton, N.J.). 1598:353-372 [DOI] 10.1007/978-1-4939-6952-4_18. [PMID] 28508372.
2017
Neuropeptide systems and new treatments for nicotine addiction
. 234(9):1419-1437
2017
Neuropeptide systems and new treatments for nicotine addiction.
Psychopharmacology. 234(9-10):1419-1437 [DOI] 10.1007/s00213-016-4513-5. [PMID] 28028605.
2017
Pros and Cons of Medical Cannabis use by People with Chronic Brain Disorders.
Current neuropharmacology. 15(6):800-814 [DOI] 10.2174/1570159X14666161101095325. [PMID] 27804883.
2017
Reducing the Prevalence of Smoking: Policy Measures and Focusing on Specific Populations.
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. 19(9):1003-1004 [DOI] 10.1093/ntr/ntx154. [PMID] 29054127.
2017
Reward Processing and Smoking.
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. 19(6):661-662 [DOI] 10.1093/ntr/ntw303. [PMID] 28486714.
2017
The sigma-1 receptor modulates methamphetamine dysregulation of dopamine neurotransmission.
Nature communications. 8(1) [DOI] 10.1038/s41467-017-02087-x. [PMID] 29263318.
2016
Behavioral and pharmacological characterization of the effects of cannabis smoke and anandamide in rats
PLoS One. 11(4)
2016
Behavioral Characterization of the Effects of Cannabis Smoke and Anandamide in Rats.
PloS one. 11(4) [DOI] 10.1371/journal.pone.0153327. [PMID] 27065006.
2016
Overexpression of CRF in the BNST diminishes dysphoria but not anxiety-like behavior in nicotine withdrawing rats.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 26(9):1378-1389 [DOI] 10.1016/j.euroneuro.2016.07.007. [PMID] 27461514.
2016
The Psychoactive Designer Drug and Bath Salt Constituent MDPV Causes Widespread Disruption of Brain Functional Connectivity.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 41(9):2352-65 [DOI] 10.1038/npp.2016.40. [PMID] 26997298.
2015
Acute nicotine administration increases BOLD fMRI signal in brain regions involved in reward signaling and compulsive drug intake in rats
International Journal of Neuropsychopharmacology. 18(2)
2015
Chronic treatment with the vasopressin 1b receptor antagonist SSR149415 prevents the dysphoria associated with nicotine withdrawal in rats.
Behavioural brain research. 292:259-65 [DOI] 10.1016/j.bbr.2015.06.031. [PMID] 26112757.
2015
Corrigendum: Temporal MRI characterization, neurobiochemical and neurobehavioral changes in a mouse repetitive concussive head injury model.
Scientific reports. 5 [DOI] 10.1038/srep15922. [PMID] 26679741.
2015
Temporal MRI characterization, neurobiochemical and neurobehavioral changes in a mouse repetitive concussive head injury model.
Scientific reports. 5 [DOI] 10.1038/srep11178. [PMID] 26058556.
2014
Behavioral Alterations and Dependence Following Acute and Chronic Exposure To Cannabis Smoke
Neuropsychopharmacology. 39(1):S599-S600
2014
Sustained AAV-mediated overexpression of CRF in the central amygdala diminishes the depressive-like state associated with nicotine withdrawal.
Translational psychiatry. 4 [DOI] 10.1038/tp.2014.25. [PMID] 24755994.
2014
Varenicline and cytisine diminish the dysphoric-like state associated with spontaneous nicotine withdrawal in rats.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 39(2):455-65 [DOI] 10.1038/npp.2013.216. [PMID] 23966067.
2013
Anorexic effects of intra-VTA leptin are similar in low-fat and high-fat-fed rats but attenuated in a subgroup of high-fat-fed obese rats.
Pharmacology, biochemistry, and behavior. 103(3):573-81 [DOI] 10.1016/j.pbb.2012.10.012. [PMID] 23107643.
2012
Blockade of Crf1 Receptors in the Central Nucleus of the Amygdala Attenuates the Dysphoria Associated With Nicotine Withdrawal in Rats
Pharmacology Biochemistry and Behavior. 101(1):62-68 [DOI] 10.1016/j.pbb.2011.12.001. [PMID] 22182462.
2012
Investigation of the Role of Corticotropin-Releasing Factor Receptors Within the Central Amygdala and Basolateral Amygdala During Nicotine Withdrawal in Rats
The FASEB's Journal. 26
2012
Tobacco Addiction and the Dysregulation of Brain Stress Systems
Neuroscience and Biobehavioral Reviews. 36(5):1418-1441 [DOI] 10.1016/j.neubiorev.2012.02.015. [PMID] 22405889.
2011
Effects of Insulin and Leptin in the Ventral Tegmental Area and Arcuate Hypothalamic Nucleus On Food Intake and Brain Reward Function in Female Rats
Behavioural brain research. 219(2):254-264 [DOI] 10.1016/j.bbr.2011.01.020. [PMID] 21255613.
2011
Repeated Pre-Exposure To Tobacco Smoke Potentiates Subsequent Locomotor Responses To Nicotine and Tobacco Smoke But Not Amphetamine in Adult Rats
Pharmacology Biochemistry and Behavior. 100(1):109-118 [DOI] 10.1016/j.pbb.2011.08.005. [PMID] 21871478.
2011
Stimulation of Alpha 2-Adrenergic Receptors in the Central Nucleus of the Amygdala Attenuates Stress-Induced Reinstatement of Nicotine Seeking in Rats
Neuropharmacology. 60(2-3):303-311 [DOI] 10.1016/j.neuropharm.2010.09.013. [PMID] 20854830.
2011
Tobacco Smoke Diminishes Neurogenesis and Promotes Gliogenesis in the Dentate Gyrus of Adolescent Rats
Brain Research. 1413:32-42 [DOI] 10.1016/j.brainres.2011.07.041. [PMID] 21840504.
2010
Corticotropin-releasing factor mediates the dysphoria-like state associated with alcohol withdrawal in rats.
Behavioural brain research. 210(2):288-91 [DOI] 10.1016/j.bbr.2010.02.043. [PMID] 20193713.
2010
Effects of Prazosin, Clonidine, and Propranolol On the Elevations in Brain Reward Thresholds and Somatic Signs Associated With Nicotine Withdrawal in Rats
Psychopharmacology. 212(4):485-499 [DOI] 10.1007/s00213-010-1970-0. [PMID] 20697697.
2010
Preadolescent Tobacco Smoke Exposure Leads To Acute Nicotine Dependence But Does Not Affect the Rewarding Effects of Nicotine Or Nicotine Withdrawal in Adulthood in Rats
Pharmacology Biochemistry and Behavior. 95(4):401-409 [DOI] 10.1016/j.pbb.2010.02.018. [PMID] 20211642.
2010
Tobacco smoke exposure induces nicotine dependence in rats.
Psychopharmacology. 208(1):143-58 [DOI] 10.1007/s00213-009-1716-z. [PMID] 19936715.
2009
Corticotropin-Releasing Factor Within the Central Nucleus of the Amygdala and the Nucleus Accumbens Shell Mediates the Negative Affective State of Nicotine Withdrawal in Rats
Neuropsychopharmacology. 34(7):1743-1752 [DOI] 10.1038/npp.2008.231. [PMID] 19145226.
2009
Corticotropin-releasing factor-1 receptor activation mediates nicotine withdrawal-induced deficit in brain reward function and stress-induced relapse.
Biological psychiatry. 66(2):110-7 [DOI] 10.1016/j.biopsych.2009.01.010. [PMID] 19217073.
2009
Deficit in Brain Reward Function and Acute and Protracted Anxiety-Like Behavior After Discontinuation of a Chronic Alcohol Liquid Diet in Rats
Psychopharmacology. 203(3):629-640 [DOI] 10.1007/s00213-008-1409-z. [PMID] 19048233.
2009
Kappa-Opioid Receptor Signaling and Brain Reward Function
Brain Research Reviews. 62(1):127-146 [DOI] 10.1016/j.brainresrev.2009.09.008. [PMID] 19804796.
2009
Methamphetamine- and trauma-induced brain injuries: comparative cellular and molecular neurobiological substrates.
Biological psychiatry. 66(2):118-27 [DOI] 10.1016/j.biopsych.2009.02.021. [PMID] 19345341.
2009
Pk/Pd Studies Focusing On Physical Dependence of Fentanyl in Rats
Clinical Pharmacology & Therapeutics. 85
2008
Effects of Fentanyl Dose and Exposure Duration On the Affective and Somatic Signs of Fentanyl Withdrawal in Rats
Neuropharmacology. 55(5):812-818 [DOI] 10.1016/j.neuropharm.2008.06.034. [PMID] 18634811.
2008
Effects of Npy and the Specific Y1 Receptor Agonist {[}D-His(26)]-Npy On the Deficit in Brain Reward Function and Somatic Signs Associated With Nicotine Withdrawal in Rats
Neuropeptides. 42(3):215-227 [DOI] 10.1016/j.npep.2008.03.004. [PMID] 18468678.
2007
Anabolic Steroid Abuse: Neurobiological Substrates and Psychiatric Comorbidity.
Journal of Addictive Diseases. 25(1):33-45
2007
Antagonism of CRF receptors prevents the deficit in brain reward function associated with precipitated nicotine withdrawal in rats.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 32(4):955-63 [PMID] 16943772.
View on: PubMed
2007
Effects of the CRF receptor antagonist D-Phe CRF(12-41) and the α2-adrenergic receptor agonist clonidine on stress-induced reinstatement of nicotine-seeking behavior in rats.
Neuropharmacology. 53:958-66
2007
The effects of buprenorphine on fentanyl withdrawal in rats.
Psychopharmacology. 191(4):931-41 [DOI] 10.1007/s00213-006-0670-2. [PMID] 17211652.
2006
Diminished nicotine withdrawal in adolescent rats: implications for vulnerability to addiction.
. 186:612-619
2006
Severe deficit in brain reward function associated with fentanyl withdrawal in rats.
Biological psychiatry. 59(5):477-80 [PMID] 16169528.
View on: PubMed
2005
Decreased sensitivity to the effects of dopamine D1-like, but not D2-like, receptor antagonism in the posterior hypothalamic region/anterior ventral tegmental area on brain reward function during chronic exposure to nicotine in rats.
Brain Research. 1058:91-100
2005
Differential regulation of Agouti-related protein and Neuropeptide Y in hypothalamic neurons following a stressful event.
Molecular Endocrinology. 35:159-64
2005
Prolonged nicotine exposure does not alter GABAB receptor-mediated regulation of brain reward function.
Neuropharmacology. 49:953-962
2005
The role of corticotropin-releasing factor-like peptides in cannabis, nicotine, and alcohol dependence.
Pediatric Critical Care Medicine. 49(3):505-28 [DOI] 10.1016/j.brainresrev.2005.01.007. [PMID] 16269317.
2004
Adaptations in the ventral tegmental area associated with the negative affective signs of nicotine withdrawal.
Neuropharmacology. 47:572-579
2004
Neurobiological Mechanisms in Addictive and Psychiatric Disorders.
. 27(4):661-674
2004
Nicotine withdrawal in adolescent and adult rats.
Annals of the New York Academy of Sciences. 1021:167-174
2003
Characterization of the effects of bupropion on the reinforcing and incentive-motivational properties of nicotine and food in rats.
Synapse. 50:20-28
2003
The antismoking and antidepresssant agent bupropion enhances brain reward function and reverses the affective and somatic aspects of nicotine withdrawal.
. 168:347-358
2002
Exposure to chronic mild stress alters thresholds for lateral hypothalamic stimulation reward and subsequent responsiveness to amphetamine.
Neuroscience. 114(4):925-33 [PMID] 12379248.
View on: PubMed
2002
Long-lasting changes in central nervous system processing of visceral afferent stimuli after stress.
Gastroenterology. 123:1216-1225
2001
Effect of a benzodiazepine receptor agonist and corticotropin-releasing hormone receptor antagonists on long-term foot-shock-induced increase in defensive withdrawal behavior.
Psychopharmacology. 158(2):132-9 [PMID] 11702086.
View on: PubMed
2001
Effect of a benzodiazepine receptor agonist and CRH receptor antagonists on long-term foot shocks induced increase in defensive withdrawal behavior.
. 158:132-139
2001
Long-term sensitization of cardiovascular stress responses after a single stressful experience.
Physiology & Behavior. 73:81-86
2001
LY354740 attenuates the expression of long-term behavioral sensitization induced by a single session of foot shocks.
European journal of pharmacology. 426(1-2):77-80 [PMID] 11525774.
View on: PubMed
2001
Stress-induced sensitization of CRH-ir but not P-CREB-ir responsivity in the rat central nervous system.
Brain research. 908(2):187-96 [PMID] 11454329.
View on: PubMed
2000
Endogenous corticotropin-releasing hormone inhibits conditioned-fear-induced vagal activation in the rat.
European journal of pharmacology. 389(1):89-98 [PMID] 10686300.
View on: PubMed
2000
Long-lasting stress sensitisation.
European Journal of Pharmacology. 405:217-224
2000
The role of the CRH type 1 receptor in autonomic responses to corticotropin- releasing hormone in the rat.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 22(4):388-99 [PMID] 10700658.
View on: PubMed
2000
The role of the CRH type 1 receptor in autonomic responses to corticotropin-releasing hormone in the rat.
Neuropsychology. 22:388-399
1999
Long-term sensitization of Fos-responsivity in the rat central nervous system after a single stressful experience.
Brain research. 819(1-2):15-22 [PMID] 10082856.
View on: PubMed
1999
Sex differences in long-term stress-induced colonic, behavioural and hormonal disturbances.
Life sciences. 65(26):2837-49 [PMID] 10622273.
View on: PubMed

Grants

Sep 2020 ACTIVE
Opioid and cannabinoid interactions in pain and reward
Role: Co-Investigator
Funding: NATL INST OF HLTH NIDA
Mar 2019 ACTIVE
Crosstalk between dopamine and glucocorticoids in high levels of nicotine intake and anhedonia in rats
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDA
Dec 2018 – Nov 2020
Opioid use disorders: UF Pharmacy medications discovery and development
Role: Project Manager
Funding: NATL INST OF HLTH NIDA
Jul 2016 – Jan 2021
Tobacco: relationship between reduced nicotine content and reinforcement in rats
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDA
May 2016 – Jan 2018
Sex differences in the mechanisms that promote nicotine reward and withdrawal
Role: Principal Investigator
Funding: THE UNIVERSITY OF TEXAS AT EL PASO via NATL INST OF HLTH

Education

Postdoc, Neuropharmacology
2001-2004 · The Scripps Research Institute, San Diego
PhD, Neuropharmacology
1997-2001 · Utrecht University, Utrecht, Netherlands
MS, Animal Science
1994-1997 · Wageningen University, Wageningen, Netherlands
BS, Animal Science
1990-1994 · Dronten Professional Agricultural University, Dronten, Netherlands

Teaching Profile

Courses Taught
2016-2018,2020-2021
MDU4001 Introduction to Medical Science Seminar 1
2017-2018
MDT7840 Elect Top/Psychiatry
2015
GMS7794 Neuroscience Seminar
2009-2011
MEL4001 Intro Med Sci Sem 1
2009-2010
IDH4917 Undergrad Research
2009
IDS4906 Interdisciplinary Thesis Research

Contact Details

Phones:
Business:
(352) 294-4931
Emails:
Business:
awbruijn@ufl.edu