Stanislav Svetlov, M.D., Ph.D.

Stanislav Svetlov, MD, PhD Associate Professor

Stanislav Svetlov, MD, PhD
Associate Professor

Contact Information

e-mail ssvetlov@ufl.edu

Current Position

Research Associate Professor
Departments of Psychiatry and Medicine
University of Florida (2011-current)

Associate Faculty Member
UF Health Shands Cancer Center (2007-current)

Expertise Area

Biomarkers & therapeutics of brain injury, PTSD & military polytrauma and sepsis.

Honors and Awards

Internationally recognized awards and patents for inventions in diagnostics and therapeutics, issued and pending patents:

The Caroline tum Suden/Frances A. Hillebrandt Professional Award for Meritorious

Research from the American Physiological Society; Vanderbilt University/SERLC

Award; The American Liver Foundation Charles Trey, MD Liver Scholar Award;

Congressionally Directed Medical Research Awards 2007 and 2010

 

Patents Issued

‘Detection of cannabinoid receptor biomarkers and uses thereof’ US 7,611,858 B1; ‘Biomarkers of liver injury’ US 7,645,584;   WO2006107846 LIPID COMPOUNDS FOR SUPPRESSION OF TUMORIGENESIS, US 8,871,983 WO2010017550 (A2), WO2010017550 (A3)

Patents Pending

Biomarker Assay of Neurological Conditions US2013029859 (A1);  Biomarkers of Liver Injury CA 2635198; EU P 2006749137; JP 2008504487; Compositions and Methods Relating to Argininosuccinate Synthetase PCT/US11/022561

Previous positions and research experience

2006-2007  Research Associate Professor, Department of Physiological Sciences, University of Florida, Gainesville FL; Biomarkers and therapeutics of polytrauma.

2003-2006   Research Assistant Professor, Center for Proteomics & Biomarker Research, University of Florida; Mechanisms of polytrauma.

2000-2003    Assistant Professor, Department of Pathology, Gainesville, Florida; Functional lipidomics and inflammation.

1997-1999    Research Fellow/Associate Research Scientist, Department of Pathology, Yale University School of Medicine, New Haven, CT. Functional lipidomics : lipid-dependent mechanisms of hepatic injury and hepatobiliary inflammation.

1993-1996  Postdoctoral Associate, Laboratory of Dr. Hanahan and Dr. Olson, Department of Biochemistry, University of Texas Health Science Center, San Antonio,TX; Lipid mediators and their receptors in inflammation.

1991-1992 Research Associate, Laboratory of Molecular Pathology, Institute of Pediatrics and Children’s Surgery, Moscow, Russia; GPCR and inflammation.

1992  Visiting Scientist, Laboratory of Eicosanoid Research, Free University of Berlin, Germany; Eicosanoids and PAF in vascular inflammation.

1990   MD/PhD Exchange Scholarship, Laboratory of Vascular Pathology, Institute Henri Beaufour/IPSEN Pharmaceuticals, Paris, France; Purinergic adenosine receptors and vascular inflammation.

1985-1986  Clinical Research Associate, Laboratory of Toxicology, Central Naval Hospital #32, Moscow, Russia. Military toxicology: hepato- and nephrotoxicity. Sepsis in soldiers wounded in Afghanistan.

1984-1985 Jr. Research Fellow, Laboratory of Toxicology, Institute for Biological Screening of Chemical Compounds, Moscow, Russia. Screening of hepato- and nephrotoxicity.

Education

1978-1983   M.D. 2-d State Medical Institute named after N. I. Pirogov, Moscow, Russia
Internship and Diploma in Medical Pharmacology & Radiobiology.

1987-1991   Ph.D. in Molecular Pathology-Institute of Pediatrics and Children’s Surgery,
Department of Nephrology, Laboratory of Molecular Pathology, Moscow, Russia. PhD
thesis: “Platelet-activating factor, eicosanoids and platelet functions in immune nephropathies”

1992-1996 Postdoctoral Research fellow, Department of Biochemistry, University of Texas
Health Science Center at San Antonio

Professional Societies and Foundations

American Association for the Study of Liver Diseases (1999-current), American Society for Neurochemistry (2004-current), American Physiological Society (AJP) (1996 – current), American Association for Advancement of Sciences (2001-current). International Liver Cancer Association (ILCA) (2010-present)

Ed hoc Reviewer for Scientific Journals

Molecular Pharmacology, Biochemica Biophysica Acta, Hepatology, Laboratory Investigation, Journal of Hepatology, Journal of Receptors, Ligands and Ion Channels; Journal of Neurotrauma

Board membership/Expert panels

2002    Organizer and Co-Chair : Mini-Simposium “Lysophospholipids and regulation of apoptosis’ at IV International Congress on Pathophysiology,

2006    National Science Foundation: Expert panel ‘Disease Diagnostics and Prognostics’

2007-present Editorial Board member ‘Journal of Receptors, Ligands and Ion Channels’

2008    Invited member of Advisory Panel of Department of Defense “Blast Induced Brain Injury”, St. Louis

2009    NIH Study Section Review ZAA1 DD (03)

2010-2014-DoD expert review panel on Blast-induced neurotrauma;

2014-current-Neurology (open access): Editorial Board Member

Research Funding

Ongoing:

VA I01RX001499 (PI- VandeVord, Virginia Tech & Salem VA Medical Center) 04/2015-03/2019 Evaluating Causative Effects of Single/Multiple Neurotrauma on Neurodegeneration.
Role- PI on UF subcontract.
The goal is to establish and characterize blood protein biomarkers of chronic TBI and CTE in blast exposed rat models.

Pending:

W81XWH-BAA-14-1-14325001 (Svetlov-PI) ‘MicroRNA panel as novel biomarkers for mTBI’ Department of Defense BAA, 3 years, $3M.

R41DK108418-01 Phase I STTR (PI-Svetlov) Topical fatty acid-based treatment for skin pathology, 1 year, $225,000

PR161494 BAA Pre-Proposal: AIP therapeutics for topical treatment of skin and wound infections.  3 years, $1.2M

W81XWH-16-R-BAA1 BA160551 Pre-Proposal: Neurorepair mechanisms following exposure to severe blast forces vs penetrating brain injury. 4 years, $3.1M

Completed Research Support

W81XWH-10-1-0876 Svetlov (PI)             09/15/2010-09/14/2014
CDMRP Investigator-Initiated Research Award through Department of Defense
Molecular Signatures and Diagnostic Biomarkers of Cumulative, Blast-Graded Mild TBI.
Project Role: Principal Investigator
Objectives: develop model and establish characteristics of mild brain injury after low level multiple blast exposures in experimental animals.

W81XWH-07-TBI-NIA Svetlov (PI)             05/01/08-04/30/11
Pathological fingerprints, systems biology and biomarkers of blast induced injury.
The goals are to validate experimental model of blast induced brain and systems injury in rats, investigate mechanisms and preliminary elucidate biomarkers of blast brain injury.

N00014-06-1-1029  Hayes (PI)                 09/01/06-08/31/08
Biomarkers for Blast Induced Brain Injury. The goal was to develop approach for diagnosing blast induced injury. Role: Co-PI

1R43AI094877-01 Svetlov (PI) NIH NIAID SBIR phase I
Title: Recombinant hepatic argininosuccinate synthase (rASS) for treatment of sepsis/endotoxemia in polytrauma.
Project Role: Principal Investigator
Objectives are to develop and validate a new biologic/therapeutic, an engineered recombinant human ASS, which will be beneficial for treatment of sepsis/endotoxemia during polytrauma. Project time line: 04/01/2011 – 03/31/2014

R43 DK074205  Svetlov (PI)                   10/01/06-9/31/07
“Novel biomarker for liver ischemia/reperfusion (I/R)-induced injury. The goal of this project was to develop a novel diagnostic of ischemia-reperfusion liver injury. Phase I of SBIR. Role:PI.

Publications (full size papers without abstracts):

Svetlov SI, Prima V, Zhang Z , Curley KC, Kobeissy F, Moghieb A and Wang KKW (2015) Acute and Subacute Differential Gene Expression in Rat Midbrain Following Blast Exposure Compared to Mechanical Brain Trauma. J Neurol Neurobiol http://dx.doi.org/10.16966/2379-7150.103

Adams S, Condrey JA, Wen Tsai H, Svetlov SI, Prima V, Davenport PW (2015) Somatomotor and Behavioral Changes Following Traumatic Brain Injury. J Neurol Neurobiol,  http://dx.doi.org/10.16966/2379-7150.104

Kobeissy F, Mondello S, Tümer N., Toklu HZ,  Whidden MA, Kirichenko N, Zhang Z, Prima V, Yassin W, Anagli J,  Chandra  N, Svetlov SI,  Wang KKW      Assessing neuro-systemic & behavioral components in the pathophysiology of blast-related brain injury. Review. Frontiers in Neurology, Nov 2013 doi: 10.3389/fneur.2013.00186 http://www.frontiersin.org/Journal/10.3389/fneur.2013.00186/full

Prima V, Serebruany V, Svetlov A, Hayes RL, Svetlov S.  Impact of moderate blast exposures on thrombin biomarkers assessed by Calibrated Automated Thrombography (CAT) in rats. J Neurotrauma. 2013 Nov 15;30(22):1881-1887  http://online.liebertpub.com/doi/abs/10.1089/neu.2012.2758

Svetlov, S.I., Prima, V., Glushakova O, Svetlov A., Kirk, D.R., Gutierrez, H., Serebruany VL., Curley, K.C., Wang, K.K.W. and Hayes, R.L.  Neuro-glial and systemic mechanisms of pathological responses in rat models of primary blast overpressure compared to ‘composite’ blast. Frontiers in Neurotrauma, 2012, 2012; 3: 15 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3275793/

Tümer, Svetlov SI,  Whiddenh M, Kirichenko N, Prima V, Erdos B, Sherman A, Kobeissy F, Yezierski R, Scarpace PJ, Vierck C, Wang K.W. Overpressure blast-wave induced brain injury elevates oxidative stress in the hypothalamus and catecholamine biosynthesis in the rat adrenal medulla. Neuroscience Lett. 2013 544:62-7 http://www.ncbi.nlm.nih.gov/pubmed/23570732

Serebruany V, Sani Y, Lynch D, Schevchuck A, Svetlov SI, Fong A, Thevathasan L, Hanley D. Effects of dabigatran in vitro on thrombin biomarkers by Calibrated Automated Thrombography in patients after ischemic stroke. J Thromb Thrombolysis. 2012 Jan;33(1):22-7. http://www.ncbi.nlm.nih.gov/pubmed/22065286

Svetlov, S.I., Prima, V., Kirk, D.R., Gutierrez, H., Curley, K.C., Hayes, R.L., and Wang, K.K.W.  Morphologic and biochemical characterization of brain injury in a model of controlled blast overpressure exposure. J Trauma 2010, 69(4) 795-804. http://www.ncbi.nlm.nih.gov/pubmed/20215974

Svetlov, S.I., Larner, S.F., Kirk, D.R., Atkinson, J., Hayes, R.L., and Wang, K.K..

Biomarkers of blast-induced neurotrauma: profiling molecular and cellular mechanisms of blast brain injury. J Neurotrauma 2009, 26:913-921. http://www.ncbi.nlm.nih.gov/pubmed/19422293

Prima V, Cao M, and Svetlov SI.  ASS and SULT2A1 are Novel and Sensitive Biomarkers of Acute Hepatic Injury-A Comparative Study in Animal Models. J of Liver (omics) 2013,Jan 10; 2 (1) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3665291/

Cao M, Prima V, and Svetlov SI. Argininosuccinate synthase as a novel biomarker for inflammatory conditions. Biomarkers. 2013 May 2013, Vol. 18, No. 3,  242-249 More: http://informahealthcare.com/doi/abs/10.3109/1354750X.2013.773080

Cao M, Prima V, Nelson D, and  Svetlov SI. Composite fatty acid ether amides suppress growth of liver cancer cells in vitro and in an in vivo allograft mouse model. Cell Oncol. 2013 Jun;36(3):247-257  http://www.ncbi.nlm.nih.gov/pubmed/23619943

McGill MR, Cao M, Sharpe MR, Williams CD, Curry SC, Jaeschke H, and Svetlov SI Argininosuccinate synthetase as a plasma biomarker of liver injury after acetaminophen overdose in rodents and humans. Biomarkers. 2014 May;19(3):222-30 http://www.ncbi.nlm.nih.gov/pubmed/24597531

Prima V, Wang A. K, Molina G, Wang K.K.W, Svetlov, S. I.    Inhibition of LPS toxicity by hepatic argininosuccinate synthase (ASS): novel roles for ASS in innate immune responses to bacterial infection.  Int. Immunopharmacology, 2011, 11(9):1180-8

Complete List of Published Work in MyBibliography: 

http://www.ncbi.nlm.nih.gov/sites/myncbi/1HiabrIKD2Vk5/bibliography/47999703/public/?