Barry Setlow, PhD
Department of Psychiatry
University of Florida College of Medicine
PO Box 100256
Gainesville, FL 32610-0256
Office: MBI Building
Phone: 294-5203 (office), 294-5047 (lab)
1994 B.A. Psychology, Yale University
1998 Ph.D. Biological Sciences, Department of Neurobiology and Behavior, University of California, Irvine
1998-2002 Post-Doctoral Fellow, Dept. of Psychological and Brain Sciences, JohnsHopkins University
Current Research Focus
Much of the research in our laboratory concerns interactions between cognition, motivation, and drugs of abuse. In some of this work, we investigate the long-term effects of chronic drug exposure on cognitive/motivational outcomes, with a particular focus on decision-making processes (for example, risky and impulsive decision-making) and the neural mechanisms underlying drug-induced alterations in such processes. In other work, we investigate how individual differences in risky and impulsive decision-making predict propensity for future drug use. This work uses a variety of techniques in rodent models to identify behavioral and neurobiological mechanisms that mediate relationships between decision-making and drug abuse, with the ultimate goal of identifying therapeutic targets for both disordered decision-making and addiction. Finally, we collaborate with other laboratories on projects concerning the behavioral and neural basis of age-related cognitive decline.
Simon, N. W., Gilbert, R. J., Mayse, J. D., Bizon, J. L., & Setlow, B. (2009). Balancing risk and reward: A rat model of risky decision-making. Neuropsychopharmacology. 34, 2208-2217.
Setlow, B., Mendez, I. A., Mitchell, M. R., & Simon, N. W. (2009). Effects of chronic administration of drugs of abuse on impulsive choice (delay discounting) in animal models. Behavioural Pharmacology. 20, 380-389.
Simon, N. W., LaSarge, C. L., Montgomery, K. S., Williams, M. T., Mendez, I. A., Setlow, B., & Bizon, J. L. (2010). Good things come to those who wait; attenuated discounting of delayed rewards in aged Fischer 344 rats. Neurobiology of Aging. 31, 853-862.
Mendez, I. A., Simon, N. W., Hart, N., Mitchell, M. R., Nation, J. R., Wellman, P. J., & Setlow, B. (2010). Self-administered cocaine causes lasting increases in impulsive choice in a delay discounting task. Behavioral Neuroscience. 124, 470-477.
Mitchell, M. R., Vokes, C. M., Blankenship, A. L., Simon, N. W., & Setlow, B. (2011). Effects of acute administration of nicotine, amphetamine, diazepam, morphine, and ethanol on risky decision-making in rats. Psychopharmacology. 218, 703-712.
Simon N. W., Montgomery, K. S., Beas, B. S., Mitchell, M. R., LaSarge, C. L., Mendez, I. A., Baneulos, C., Vokes, C. M., Taylor, A. B., Haberman, R. P., Bizon, J. L., & Setlow, B. (2011). Dopaminergic modulation of risky decision-making. The Journal of Neuroscience. 31, 17460-17470.
Gilbert, R.J., Mitchell, M.R., Simon, N.W., Bañuelos, C., Setlow, B., & Bizon J.L. (2012). Risk, reward, and decision-making in a rodent model of cognitive aging. Frontiers in Neuroscience. 5, 144.
Mitchell, M. R., Mendez, I. A., Vokes, C. M., Damborsky, J. C., Winzer-Serhan, U. H., & Setlow, B. (2012). Effects of developmental nicotine exposure in rats on decision-making in adulthood. Behavioural Pharmacology. 23, 34-42.
Wallis, D., Hill, D. S., Mendez, I. A., Abbott, L. C., Finnell, R. H., Wellman, P. J., & Setlow, B. (2012). Initial characterization of mice null for Lphn3, a gene implicated in ADHD and addiction. Brain Research. 1463, 85-92.
Mendez, I. A., Gilbert, R. J., Bizon, J. L., & Setlow, B. (2012). Effects of acute administration of nicotinic and muscarinic cholinergic agonists and antagonists on performance in different cost-benefit decision making tasks in rats. Psychopharmacology. 224, 489-499.
Mendez, I. A., Damborsky, J. C., Bizon, J. L., Winzer-Serhan, U. H., & Setlow, B. (2013). α4β2* and α7 nicotinic acetylcholine receptor binding predicts choice preference in two cost benefit decision making tasks. Neuroscience. 230, 121-131.
Simon N. W., Beas, B. S., Montgomery, K. S., Haberman, R. P., Bizon, J. L., & Setlow, B. (in press). Prefrontal cortical-striatal dopamine receptor mRNA expression predicts distinct forms of impulsivity. European Journal of Neuroscience.
Beas, B. S., Setlow, B., & Bizon, J. L. (in press). Distinct manifestations of executive dysfunction in aged rats. Neurobiology of Aging.