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Kevin K.W. Wang, PhD

Kevin Wang, PhD Associate Professor

Kevin Wang, PhD
Associate Professor

Position

Executive Director
Center for Neuroproteomics & Biomarkers Research
Chief – Translational Research
Associate Professor of Psychiatry, Neuroscience & Physiological Science

Contact Information

University of Florida,
McKnight Brain Institute, L4-100L
1149 South Newell Drive, Gainesville
Gainesville, FL 32611, USA
Office 352-294-4933
Fax 352-392-2579
kwang@ufl.edu

Training

B.Sc. Biochemistry, with minor in Biomedical Science, University of Guelph, Guelph, Canada
Ph.D. Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada
Postdoctoral Fellowship: Wayne State University, Detroit, Michigan

Biography

Dr. Wang obtained his Ph.D. in Pharmaceutical Sciences with Distinction from the University of British Columbia in Vancouver in 1989. He is internationally recognized for his original contributions to the fields of CNS disorders-linked proteolytic enzymes, neuroproteomics and disease biomarker discovery. He joined Parke-Davis Pharmaceutical Research (Ann Arbor, MI) in 1991, and following the company’s merger with Pfizer Inc. (2000), he became Group Leader of CNS Therapeutics/CNS new targets team. He also co-chaired the Far East Scientific Opportunity Team. In 2002, he became Associate Professor of Psychiatry at the University of Florida (Gainesville, FL), Associate Director of the Center for Traumatic Brain Injury Studies and Director of the Center of Neuroproteomics and Biomarkers Research. In 2002, he is a Founder of biotechnology company Banyan Biomarkers Inc. (Alachua, Florida). In 2007, he transitioned to Banyan as full-time Chief Scientific Officer and the Center Director of the Center of Innovative Research. . Dr. Wang has contributed significantly to the discovery, sensitive sandwich ELISA development of two acute TBI protein biomarkers (UCH-L1 and GFAP-BDP) and their diagnostic utility characterization in several animal and human TBI spectrum studies. This TBI biomarker tandem is now in pivotal study for FDA approval as a new first-in-class in vitro diagnostic (IVD) test for mild-moderate TBI (ALERT Trial). In 2011, he rejoined the University of Florida McKnight Brain Institute as Executive Director of the Center of Neuroproteomics and Biomarkers Research /Chief – Translational Research & Associate Professor of Psychiatry and Neuroscience and to rededicate himself to basic and translational research. He is also Chair Professor of the Taipei Medical University.

His research also expanded to proteomic technologies to psychiatric disorders because neuronal injury biomarkers are also highly relevant to psychiatric diseases such as substance abuse and schizophrenia. His laboratory is developing animal model for substance abuse (ecstasy (MDMA), methamphetamine and alcohol abuse, bath salts/designer psychostimulants). In parallel, his group is employing an integrated proteomics-based approach to discover novel biomarkers for these neurological and psychiatric diseases. These technologies include: (1) 2D gel electrophoresis-MALDI-TOF, (2) 2D-LC-MS/MS, (3) CAX-PAGE RPLC-MS/MS, and (4) monoclonal antibody array.

Dr. Wang published more than 200 peer-reviewed papers, reviews and book chapters and co-authored eight US patents. He co-edited four books on proteases, neuroproteomics and biomarkers for CNS disorders. He also serves on five international journal’s Editorial Board. Dr. Wang was Past President  and is current Council member of the National Neurotrauma Society (USA).

His research interests include neuro-proteomics, CNS Injury, neurodegeneration, substance abuse research (methamphetamine, MDMA, nath salts), protein post-translational modification (proteases / protein kinases), biomarkers discovery and assay development, diagnostics, therapeutic development and theranostics.

Council Member / Past President

National Neurotrauma Society

Associate Editor

Translational Proteomics (Elsevier)

Frontier in Neurotrauma

http://www.researchgate.net/profile/Kevin_Wang6

 

EXPERIENCE

Nov. 2011 – pres.

Executive Director

Center for Neuroproteomics and Biomarkers Research

Chief – Translational Research

Associate Professor

Departments of Psychiatry & Neuroscience

McKnight Brain Institute

University of Florida

.   WOC-Research Scientist, BRRC (Brain Rehabilitation Research Center), NF/SG Veterans Health System, Malcom Randall Veterans Affairs Medical Center, Gainesville, FL

Chair Professor

Jan 2012 – pres.

Taipei Medical University

Taipei, Republic of China

Council Member / Past President

July 2011 – pres.                                 

National Neurotrauma Society

 

Chief Operations & Scientific Officer

Dec. 2009 – Nov. 2011

Banyan Biomarkers, Inc., Alachua, FL

Executive Director, Center of Innovative Research

July 2007 – Nov. 2011

Banyan Biomarkers, Inc., Alachua, FL

                                                     

Chief Scientific Officer

July 2004 –Dec. 2009

Banyan Biomarkers, Inc., Alachua, FL

Founder

July 2004 – pres.

Banyan Biomarkers, Inc., Alachua, FL

 Director

July 2003–June 2007.

Center for Neuroproteomics and Biomarkers Research

McKnight Brain Institute

University of Florida, Gainesville, FL

Oct. 2007 – Nov. 2011.                 Courtesy Assoc. Professor

                                                              Department of Psychiatry & Neuroscience

                                                              McKnight Brain Institute

                                                              University of Florida

Feb 2010 – Jan 2013                      Visiting Professor

                                                             Taipei Medical University

                                                             Taipei, Republic of China

July 2002 – Sept. 2007.                 Associate Professor

                                                            Department of Psychiatry & Neuroscience

                                                            McKnight Brain Institute of the University of Florida

                                                            Gainesville, FL

July 2002 – 2007                             Associate Director

                                                            Center for Traumatic Brain Injury Studies (CTBIS)

                                                            McKnight Brain Institute

                                                            University of Florida, Gainesville, FL

Jan. 1997 – pres.                             Adjunct Assistant Professor

                                                             Dept. Pharmacology, School of Medicine

                                                             Univ. of Michigan, Ann Arbor, MI

Feb. 2001 – June 2002                   Associate Research Fellow / Group Leader

                                                             Dept. CNS Molecular Sciences

                                                             Pfizer Global Research & Development (Ann Arbor)

Jan. 1998 – March. 2001                Co-Chair

                                                             Far East Scientific Opportunities Committee (FESOC)

                                                             Pfizer Global Research & Development (Ann Arbor)

June 2000 – Feb. 2001                  Associate Research Fellow / Group Leader

                                                              Dept. Neuroscience Pharmacology

                                                              Pfizer Global Research & Development (Ann Arbor)

Oct. 1999 – June 2000                   Associate Research Fellow / Group Leader

                                                           Dept. Neuroscience Therapeutics,

                                                           Parke-Davis Pharmaceutical Research

Nov. 1995 – Oct. 1999                   Senior Research Associate

                                                            Dept. Neuroscience Therapeutics,

                                                            Parke-Davis Pharmaceutical Research, Ann Arbor, MI

April 1992 – Nov. 1995                    Research Associate

                                                             Dept. Neuroscience Therapeutics,

                                                             Parke-Davis Pharmaceutical Research

Feb. 1991 – April 1992                     Senior Scientist

                                                              Dept. Pharmacology, Division of Neurosciences

                                                              Parke-Davis Pharmaceutical Research Division

                                                              Warner Lambert Company, Ann Arbor, MI, USA

Aug. 1989 – Feb. 1991                      Research Associate

                                                               Dept. of Pathology, Wayne State University

                                                               Supervisor: Dr. Tuan H. Kuo

EDITORIAL BOARD

As Associate or Section Editor

2012 – pres       [Associate Editor], Translational Proteomics (Elsevier)

2010 – pres.       [Associate Editor], Frontiers in Neurotrauma

On Editorial Board

2003- pres.      Journal of Neurotrauma

2011 – pres     Biomarkers in Medicine

1998 – pres. Cell. Mol. Biol. Letter

2010 – pres.     Frontiers in Systems Biology

2011- pres.   ISRN Neurology (http://www.isrn.com/49190246/)

2012 – pres. Asia Pacific Biotech News

2012 – pres. Neural Regeneration Research

2012 – pres.     American Journal of Neuroscience

2014 – pres. Neuroimmunoloy and Neuroinflammation (ISSN 2347-8659)

Guest Editors

2013                      Guest Editors: Wang, K.K.W., Kobeissy, F. and Stevens, S.
( (2013) Electrophoresis (Editor-in-Chief: Ziad El Rassi) 
Topic-
”Neuroproteomics: Deciphering Brain Dynamics” Impact Factor: 3.57

2012 – 13.   Section Editor: Wang, K.K.W.] Current Translational Geriatrics and Experimental Gerontology Reports. Topics: “Traumatic Brain Injury”

2013                      Guest Editors: Hayes, R.H. Mondello, S., , Tortella, F., Wang, K.K.W. (2013) Topic- “Traumatic brain injury Biomarkers”.

AWARDS & HONORS

2011-                   President, National Neurotrauma Society

2010 –                  Board Member, Board of Governors, International Brain Injury Association (since 2010)

2010-pres.          Presidium Member, The Academy for Multidisciplinary Neurotraumatology (AMN)

2010- pres.         Board Member, Board of Governors, Internat’l Brain Injury Association (IBIA)

2011-12              Biographee, Who’s Who in Science and Engineering

2009-2012         Biographee, Marquis Who’s is Who in America

7.2009                 Finalist-Health and Medicine (Corporate)-THE WORLD TECHNOLOGY AWARDS, NY

4.2009                 Discovery Spotlight Inventor, Davis Wright Tremaine

1/2009                Florida High Tech Corridor Featured : 2009 Faces of Technology”

8/2005                Rengachary Oration Award

                              Neurotrauma Society of India, Kolkata. India, (August 21, 2005)

5/1998                Parke-Davis R&D 1997 Managerial Award

8/1985                Merit Award, Canadian Soc. Of Chemistry

 

PROFESSIONAL SOCIETIES

National Neurotrauma Society (President since 2011)

International Brain Injury Association (Board member since 2010)

The Academy for Multidisciplinary Neurotraumatology (AMN) (Presidium Member since 2010)

Member American Neurotrauma Society (since 2000)

Member The New York Academy of Sciences (since 1991)

Member, Society for Neuroscience

Member American Chemical Society

 

EXTRAMURAL ACTIVITIES

-1998 -2002     Steering Committee member, Career Development Committee (CDC), Pfizer (Ann Arbor)

-1998 – 2002    Chair, Career Enhancement Subcommittee, Career Development Committee, Pfizer/Parke-Davis, Ann Arbor

-2000 –03         Scientific Advisor, Center for Traumatic Brain Injury Studies, University of Florida Brain Institute

2003 – 07         Member of Scientific Advisory Board, Interdisciplinary Center for Biomedical Research (ICBR), Univ. Florida (2003-2005)

-2004 –pres.   Board Member, Scientific Advisory Board, CepTor Corp., Hunt Valley, MD

-2005 –pres.   Panelist; Stroke Panel; bioMérieux Inc., Lyon, France

-2005                   Reviewer, University Florida Shands Cancer Center (SCC) Senior Investigator Grant Review

-2006,                Grand Awards Judge, Intel International Science Fair (Indianapolis, IN, May 9-13, 2006)

-2006                 Program Committee, 2006 National Neurotrauma Symposium (July 7 – 9, 2006 in St. Louis, MO)

-2006-               Board Member, Board of Directors, Oak Hall School, Gainesville, Florida

-2006-07           Advisory Committee member, Seeds of Science-Alachua County Science Fair Committee, Gainesville, FL

-2009 –              Elected Fellow, World Technology Network

-2011 -12              President, National Neurotrauma Society

-2012-13               Council Member, National Neurotrauma Society

 

Symposia Organized

-1992     Organizer, Symposium on Calcium Dependent Protease and Neuronal Cell Death, Ann Arbor (2/27/1992)

-1996     Organizer, Parke-Davis Minisymposium on Apoptosis, Ann Arbor (10/15/1996)

-1997     Co-Organizer, Parke-Davis / Univ. Michigan Pharmacology Poster Day, Ann Arbor (9/11/1997)

-1998     Co-Chairman, Acute Neuronal Injury: New Therapeutic Opportunities, Las Vegas (9/23-25/1998)

-1998     Co-Chairman, Colloquium on “Mitochondrial Mechanism of CNS Injury” Am. Soc. Neurochem. Meeting, New Orleans (3/14-17/1999)

-1999     Co-Chairman, FASEB Summer Conference on Calpain (6/20-24/1999), Copper Mountain, CO

-1999     Co-Organizer, Parke-Davis / Univ. Michigan Pharmacology Poster Day, Ann Arbor (9/23/1999)

-2000     Co-Organizer, Parke-Davis Minisymposium on Tauopathy (3/24/2000), Ann Arbor, MI

-2000     Chairman, Colloquium on “Tauopathy” Am. Soc. Neurochem. Meeting, Chicago, (3/26-29/2000)

-2001     Co-Chairman, FASEB Summer Conference, “Calpain System in Health and Disease”, Whitefish, Montana (June 30 -July 5, 2001)

-2001     Co-Chairman; ‘Proteases in the Heart’ Symposium, the International Society for Heart Research, Winnipeg, Canada, (July 6-11, 2001).

-2001     Co-Chair, Symposium: “Current understanding and controversy of the modes of neuronal death (apoptosis and necrosis)”, 18th Meeting of the International Society for Neurochemistry, Buenos Aires, Argentina (Aug. 26-31, 2001).

-2001     Advisory Board Member, 2nd Meeting of The International Proteolysis Society, Munich, Germany (Oct. 31 – Nov. 4, 2001)

-2001     Co-Organizer, Pfizer / Univ. Michigan Pharmacology Poster Day, Ann Arbor (12/2001)

-2002     Co-Chair, Symposium: “Biomarkers for Acute Central Nervous System Injury”, Am. Soc. Neurochem. Meeting 2002 Palm Beach, FL, June 22-27, 2002

-2002     Panelist / Speaker: NIH-NINDS Neuroproteomics Workshop (Washington D.C., Dec. 8-10, 2002)

-2003     Liaison panelist for NIH-NIAAA Council Meeting (Bethesda, MD 2-5-3003)

-2005-06 Advisory Committee, Systems Analysis, Data Mining and Optimization in Biomedicine, Univ. Florida, Gainesville, Feb 2-4 2005

-2005       Co-organizer, 4th INTERNATIONAL CONFERENCE ON BIOCHEMICAL MARKERS FOR BRAIN DAMAGE SEPTEMBER 8-10, 2005, Boothbay Harbor, Maine USA

-2006       Session Chair – Injury Biomarkers: Proteomics and non-proteomic approaches, The 24th Annual National Neurotrauma Symposium, St. Louis, MO, USA (July 7-9, 2006)

-2009       Organizing Faculty / Speaker ; 5th INTERNATIONAL CONFERENCE ON BIOCHEMICAL MARKERS FOR BRAIN DAMAGE May 11-14, 2009 (Lund, Sweden)

-2010       Panelist; Telemedicine and Advanced Technology Research Center Neurotrauma – TBI Product Line Review 09 February 2010

-2010       Sci. Program Organizer / Speaker, Calpain-FASEB-Summer Conference 2010; Carefree, Arizona, July 25-30, 2010

-2010       Faculty, 6th Pannonian CNS Injury Meeting (Pecs, Hungary); May 13-15, 2010

-2011       Chairman, Ist Annual Biomarkers in Diagnostics and Therapeutics. Singapore, Jan. 24-25, 2011

-2011       Organizing Faculty / Speaker ; 5th international conference on biochemical markers for brain damage (Lund, Sweden) May 8-11, 2011

-2012       Scientific Program Organizer, 3rd Internatl. Congress of the Asia-Oceania Neurotrauma Society In Conjunction with Annual Internatl. Congress of the Academy of Multidisciplinary Neurotraumatology (AMN) May 13-15,2012

-2012       Invited Plenary Speaker, International Brain Injury Association (IBIA) – 9th Word Congress, Edinburgh, Scotland, March 22-25, 2012

-2012       Chair, 2nd Annual Biomarkers in Diagnostics and Therapeutics. Singapore, April 25-26, 2012

-2012       Chairman, National Neurotrauma Society Symposium, Phoenix, July 12, 2012

-2013       Symposium Chair, National Neurotrauma Symposium Gaylord Opryland Resorts in Nashville, NNT-Nashville , August 4-7, 2013

-2014         Speaker,/ Chairman, 3rd Annual Biomarkers in Diagnostics and Therapeutics (BDT). Singapore, Sept. 24-25, 2014

Invited Speaker

-1989       Invited Speaker; First European Symposium on Calcium Binding Proteins, Belgium

-1989       Seminar Speaker; Institute of Biomedical Investigations, Faculty of Medicine, University Autonoma, Spain

-1990       Seminar Speaker; Department of Pharmacology, Parke-Davis Pharmaceutical Research, Warner-Lambert Company, Ann Arbor (8/90)

-1990       Seminar Speaker; Department of Biological Chemistry, University of Maryland

-1993       Invited Speaker, 36th Annual Meeting of the Canadian Federation of Biological Societies, Windsor, Canada (6/17-19/1993)

-1994       Seminar Speaker; Dept. of Pharmacology, University of Pittsburgh (9/9/94)

-1994       Seminar Speaker; Cell and Molecular Biology Program, Colorado State Univ. (10/6/94)

-1994       Seminar Speaker; School of Pharmacy, Univ. of Colorado (Denver) (10/7/94)

-1994       Seminar Speaker; Tokyo Metropolitan Institute of Medical Science, Japan (11/7/94)

-1995       Seminar Speaker; NRCC-Biotechnology Research Institute, Montreal, Canada (5/9/95)

-1995       Seminar Speaker; Dept. Biochemistry, Queen’s University at Kingston, Canada (5/10/95)

-1995       Seminar Speaker; Dept. Biochemistry, State Univ. of New York at Brooklyn (5/17/95)

-1995       Seminar Speaker; School of Dentistry, Univ. of Manitoba, Winnipeg, Canada (9/18/95)

-1995       Seminar Speaker; School of Dentistry, the Oregon Health Sciences Univ., Portland (9/19/95)

-1995       Seminar Speaker; Dept. Animal Science, Oregon State Univ., Corvallis (9/19/95)

-1995       Seminar Speaker; School of Pharmacy, Univ. of British Columbia, Vancouver, Canada (9/22/95)

-1996       Seminar Speaker; Institute of Chemical Toxicology, Wayne State Univ., Detroit, (2/23/96)

-1996       Seminar Speaker; Dept. Pharmacology, Univ. of Michigan, Ann Arbor (4/10/96)

-1996       Seminar Speaker; Dept. Neurosurgery, Univ. Texas, Houston, Texas (5/3/96)

-1996       Symposium Speaker, 5th International Conference on Alzheimer’s disease, Osaka, Japan (7/29/96)

-1996       Seminar Speaker; Senju Pharmaceutical Research, Kobe, Japan (7/30/96)

-1997       Invited Speaker, Keystone Symposium on Apoptosis, Tamarron, CO (2/20/97)

-1997       Invited Speaker; 1997 Calpain Symposium, Univ. Oxford, UK (4/14/97)

-1997       Seminar Speaker, Parke-Davis Cambridge Research Centre, Cambridge, UK (4/19/97)

-1997       Seminar Speaker, Hungarian Academy of Science, Budapest, Hungary (4/21/97)

-1997       Invited Speaker, 2nd International Neurodegeneration in Alzheimer’s disease, Parkinson’s disease and acute stroke (7/28/97)

-1998       Seminar Speaker, Dept. Biochemistry, Hong Kong Univ. Science & Technology (2/17/98)

-1998       Seminar Speaker, Dept. Pharmacology, Univ. Alabama at Birmingham (3/12/98)

-1998       Seminar Speaker, “Calpain and Caspase: Partners in Cell Death?” Univ. Kentucky, Lexington (6/3/98)

-1998       Invited speaker, Mejbaum-Katzenellebogen’s Molecular Biology Seminar (Membrane skeleton. Regulatory function in normal and abnormal cells. (6/13/98)

-1998       Invited Speaker; FASEB Summer Conference on Neurodegeneration (6/25/98)

-1998       Speaker; “Calpain and Caspase-3: Partners in Neuronal Death”, Acute Neuronal Injury: New Therapeutic Opportunities, Las Vegas (9/23/98)

-1998       Invited Speaker; Sixth Euroconference on Apoptosis (9/24/98)

-1998       Seminar Speaker, “Selective Proteolysis in Apoptosis”, Medical College Ohio, Toledo (10/8/98)

-1998       Onyx Pharmaceutical, Richmond, CA (10/19/98)

-1999       Speaker and Session Chairman; FASEB Summer Conference on Calpain (6/21/99)

-1999       Invited speaker, “Necrotic and Apoptotic Neuronal Death: From Calcium, Cytochrome C to Proteases” Am. Soc. Neurochem. Meeting, New Orleans (3/14-17/99)

-1999       Seminar Speaker, “Proteases in Cell Death”, Division of Stroke and Vascular Disease, University of Manitoba (11/9/99)

-1999       Invited Speaker, “Calpain and Caspases: Partner in Neuronal cell death”. The 2nd International Conference on Protease Inhibitors, Gainesville, Florida, (12/6/1999)

-2000       Invited Speaker, “Apoptosis: from Proteases to Protein Kinases and Phosphatase” Am. Soc. Neurochem. Meeting, Chicago, (3/26-29/2000)

-2000       Invited Speaker, “Cell Death in Ischemic CNS Demise: Novel Therapeutic Approaches” Hungarian Nuero-injury Conference, Budapest (Aug. 16-21, 2000)

-2000       Invited Speaker, International Conference on Cysteine Proteinases and their inhibitors: The New Millennium, Porotoroz, Slovenia (9/9-13/2000)

-2000       Invited Speaker, Calpain Mini-workshop, Munich, Germany (9/15/2000)

-2000       Invited Speaker, “Cell Death and Disease” Symposium, 3rd World Congress of Cellular and Molecular Biology, Jena, Germany, Oct. 8-13, 2000

-2000       Invited Seminar Speaker, Center for Paralysis Research, Purdue University (Nov. 15-16, 2000)

-2001       Invited Speaker, Cell Death Symposium, 2001 Winter Conference on Brain Research, Steamboat, CO (Jan. 20-27, 2001)

-2001       Lecturer, 19th Winter School on Proteinases and Their Inhibitors -Recent Developments, Tier, Germany (Feb. 28 – March 4, 2001)

-2001       Invited speaker and Moderator, “Therapeutic Prospects for Calpainopathy” Workshop, Paris, France (April 13-14, 2001)

-2001       Speaker, FASEB Summer Conference, “Neurodegeneration” (June 16-21, 2001)

-2001       Invited Speaker, FASEB Summer Conference, “Calpain System in Health and Disease” (June 30 -July 5 , 2001)

-2001       Speaker; “Calpain activation in oncosis and apoptosis” in Symposium “Calpain and Cardiac Function” at the International Society for Heart Research, Winnipeg, Canada, (July 6-11, 2001).

-2001       Speaker, “The role of cysteine proteases in oncotic and apoptotic neuronal death” in Symposium: “Current understanding and controversy of the modes of neuronal death (apoptosis and necrosis)”, 18th Meeting of the International Society for Neurochemistry, Buenos Aires, Argentina (Aug. 26-31, 2001).

-2001       Invited Speaker, “The expanding Mammalian Calpain Family and its involvement with human diseases”, 2nd Meeting of The International Proteolysis Society, Munich, Germany (Oct. 31 – Nov. 4, 2001)

-2001       Invited Speaker, “Dynamic Roles of Proteases in Neuronal Injury”, Traumatic Brain Injury Symposium, National Neurotrauma Meeting, San Diego, CA, (Nov. 9-10, 2001).

-2002       Invited Speaker, “Calpain-caspase interplay in oncotic and apoptotic neuronal death”, 5th International Symposium on Medicinal Chemistry of Neurodegenerative Diseases, Cancun, Mexico, Jan, 26-30, 2002

-2002       Invited speaker; “Novel calpains”, 3th Cysteine Proteases and inhibitors Conf. Portoroz, Slovenia (Sept 14-18, 2002)

-2002       Invited Speaker, “Protease Overactivation in CNS injury: Insight into Disease Mechanisms and Biomarker Opportunities”, Univ. of Florida IDP seminar, Gainesville, FL, Sept. 26, 2002

-2002       Invited Speaker, “Integrated proteomics-based approaches to the discovery of novel biomarkers for traumatic brain injury”, Proteomics in the Neuroscience, NIH, December 9-10, 2002

-2003       Invited speaker, Quantitative Neuroscience/Neural Engineering Seminar, UF, Gainesville, :Biomarkers for brain injury”. March 18, 2003

-2003     Speaker, “Biomarkers for traumatic brain injury” NINDS seminar, Bethesda, MD, April 27, 2003

-2003     Speaker, “Biomarkers for Brain Injury: CNS Injury 2nd Pannonian Symposium, May 8-10, 2003, Pecs, Hungary

-2003     Invited Speaker, ATACCC (Advanced technology Applications for Combat Casualty Care) conference. “From Neuroproteomics to Head Injury Biomarkers” August 17-22, St. Petersburg Beach, Florida

-2003     Visiting Professor, Virginia Commonwealth University, biomarkers for axonal, dendritic and synaptic pathology in brain injury (Richmond, VA, July 28, 2003)

-2003       Seminar Speaker, University of Kentucky Spinal cord and brain injury Center: “Biomarkers for Brain injury” (Lexington, KY, Sept. 9, 2003)

-2003       Seminar Speaker, Senju Pharmaceutical Co (Kobe, Japan, Nov. 9, 2003)

-2003       Speaker: Calpain Degradome: A unique subset of traumatic brain injury proteome. 3rd General Meeting for the International Proteolysis Society, Nagoya, Japan, (Nov. 10-13, 2003)

-2004       Invited Speaker, “Calpain Inhibitors for Neurologic Disease” IBC Screentech World Summit 2004, San Diego (March 21-24, 2004)

-2004       Invited Speaker, “Applying Proteomics in Brain Trauma Research”, Proteomics Workshop II (Medical Applications and Protein Networks), ULCA-IPAM, Los Angeles, CA (Aug. 16-18, 2004)

-2004       Invited Speaker, “Calpain vs. Caspase Degradomics”. Calpain Summer Conference, Tucson, AZ (June 13-17-8, 2004)

-2004       Invited Speaker, “Utilities of novel protein biomarkers for traumatic brain injury in preclinical and clinical research and drug development” Cambridge Healthtech Institute Protein Biomarkers 2004, Philadelphia (Sept. 8-11, 2004)

-2004       Plenary Speaker, “Applying Proteomics in Brain Injury Studies”, 7th International Neurotrauma Symposium, Adelaide, South Australia, (Sep 12-16, 2004).

-2004       Seminar Speaker, “Neuroproteomics and Biomarkers Discovery in Traumatic Brain Injury” Faculty of Pharmacy, University of Sydney, Australia (Sept. 17, 2004)

-2004       Seminar Speaker, “Applying Neuroproteomics to Traumatic Brain Injury Biomarkers Discovery” University of Lincoln, Canterbury, New Zealand (Sept. 20, 2004)

-2005       Invited Speaker, 3rd Pannonian Symposium on CNS Injury, Pecs, Hungary, (April 28- May 4, 2005)

-2005       Invited Speaker,”Neuroproteomics and biomarkers discovery studies using rat model of traumatic brain injury”. European Brain Research Institute; Fondazione Santa Lucia, Rome, Italy, (May 3, 2005)

-2005       Invited Speaker, talk title: Proteomic Studies Using Animal Models of Substance Abuse. International Chinese Statistical Association) Applied Statistics Symposium, Washington, DC, (June 12-15, 2005)-2005       Panelist, Proteomic Webcast, J. Genomic and Proteomics, Boston, MA (June 14, 2005)

-2005       Invited Speaker, ATACCC (Advanced technology Applications for Combat Casualty Care) conference. “Update on Head Injury Biomarkers” St. Petersburg Beach, Florida (August 14-17, 2005)

-2005       Rengachary Oration Speaker & Guest Faculty, 14th Annual Conference of Neurotrauma Society of India, Kolkata. India, (August 19-21, 2005)

-2005       Faculty Speaker, 4th International Conference on Biochemical Markers for Brain Damage Boothbay Harbor, Maine USA (September 8-10, 2005)

-2006   Speaker, “Differential Proteomic Analysis of Traumatic Brain Injury Biomarker Study” Conference on Data Mining, Systems Analysis and Optimization in Neuroscience, Gainesville, FL (February 15-17, 2006)

-2006       Faculty Speaker, “Traumatic Brain Injury Biomarkers; from discovery to validation” University of Messina Center of Neurological Studies. (March 16-19, 2006).

-2006       Session Speaker – “Α-spectrin and proteomic neural Injury Biomarkers”, The 24th Annual National Neurotrauma Symposium, St. Louis, MO, USA (July 7-9, 2006)

-2006       Seminar Speaker – “Paradigms of apoptotic, necrotic and autophagic cell death” College of Veterinary Medicine, Dept. Physiol Sci. Fall Seminar Series, Univ. Florida, Gainesville, FL. (Oct. 3, 2006)

-2007       Invited Speaker, Brain 07 Conference “Proteomics of traumatic brain injury in animal models”. Osaka, Japan, May 20-25

-2007       Invited Speaker, Calpain FASEB Conference “The Role of Calpain and Caspase in Axonal, Myelin and Dendritic Injury in Acute Brain Injury´ Snowmass, CO; July 14-19, 2007

-2007       Invited Speaker, CHI Biomarker Discovery Summit “Proteomic and Non-Proteomic Based Discovery of Protein Biomarkers for Traumatic brain injury and Stroke” ( Philadelphia) September 17-19, 2007

-2007       Invited Speaker, Downs Syndrome/chromosome 21 workshop “Neuroproteomic Methods” (Sept 28-Oct 1, 2007), Washington, D.C.

-2008       Invited Speaker, “Theranostic Approach to Diagnose and Treat Traumatic Brain Injury”, 1st Conference on Drug Design and Discovery, Feb 8-12, 2008, Dubai, UAE.

-2008       Speaker, NIH-NINDS Workshop on Blast brain Injury, (April 11, 2008), Washington, DC

-2008       Speaker, Wayne State University Blast Injury Symposium “Biomarkers for traumatic and Blast brain injury?” (May 14-16, 2008), Detroit, MI, US

-2008       Speaker, Canadian Federation of Biological Societies (6th Northern Lights Summer Conference) Winnipeg, MB, Canada, June 17 – 20, 2008 ” The Role of Calpains verses Caspase-3 in different Forms of Neuronal Cell Injury”

-2008       Speaker , 4th Pannonian Symposium on CNS Injury, “TBI Biomarkers: An Update”. September 26-28, 2008, in Pécs, Hungary

-2009       Speaker, “Novel Traumatic Brain Injury Biomarkers: From Degradomic, Proteomic And Systems Biology-Based Discovery To Assay Development And Clinical Validation” The Tokyo Metropolitan Institute of Medical Science (Rinshoken), March 3, 2009. Tokyo, Japan

-2009       Lecturer, The 2009 Nagoya Workshop on International Animal Biotechnology Partnership and Internship, March 6, 2009, Nagoya, Japan

-2009       Seminar Speaker, Chinese University of Hong Kong Clinical Neuroscience. “”Novel Traumatic Brain Injury Biomarkers: From Proteomic And Systems Biology-Based Discovery To Assay Development And Clinical Validation” March 13, 2009, Hong Kong, China.

-2009       Speaker and Session Chair: “Biomarkers for Severe TBI”. 6h BMBD Conference, Lund, Sweden, (May 14-19, 2009).

-2009       Speaker : Biomarkers for Mild TNI: Joint Symposium of the International and National Neurotrauma Societies Santa Barbara, CA . Sept. 9-11, 2009.

-2009         Speaker: “Circulating Protein Biomarkers of Brain Injury”, Annual Congress for Academy for Multidisciplinary Neurotraumatology / The Hong Kong Neurosurgery Society (HKNS) 12-14 November 2009 , Hong Kong

-2010         Seminar Speaker, UC-Davis NSF Center for Biophotonics Seminar (1-19-2010)

-2010         Speaker, Session Chair, Academy of Multidisciplinary Neurotraumatology meeting (Vermont)

-2010       Speaker, Gordon Conference (Proteolysis) May 1-6, 2010, (Lucca Italy),

-2010         Speaker, Pannonian CNS Injury Meeting (Pecs, Hungary) May 13-15, 2010

-2010         Speaker, ICRAN (Int. Conf. Recent Advanc. Neurotraumatology_ St. Petersburg, Russia , Jun 29-July 1, 2010

2010         Speaker, IBIA World Congress on Brain Injury (DC) 3-10-2010

-2010       Speaker, “International Conference on Biomedical Data & Knowledge Mining: Towards Biomarker Discovery” Chania, Crete, Greece. 7-9 Jul 2010

– 2010      Speaker, Neurotrauma Society Of India Annual Conference at CHENNAI , India, August 22-24, 2010.   (invited)

-2011       Speaker, Ist Annual Biomarkers in Diagnostics and Therapeutics. Singapore, Jan. 24-25, 2011

-2011       Speaker, SCI & Br I research forum, Indiana University April 12-15, 2011

-2011       Speaker, International Neurotrauma Society conference, April 26- May 2, 2011

-2011       Speaker, MT-3 meeting, Orlando, FL, May 2-4, 2011

-2011       Speaker (invited), SPIE, Orlando, FL, Apr 25-29*                            

-2011       Organizing Faculty / Speaker ; 5th international conference on biochemical markers for brain damage (Lund, Sweden) May 8-11, 2011

-2011     Speaker, Federal Interagency Conf. on TBI (Washington DC) June 13-15, 2011

-2011       Speaker, TBI Biomarker IPR; August 13-14, 2011, Ft. Lauderdale, Florida

-2011       Speaker, The Business of Life Sciences Florida State University, Tallahassee, FL (Nov. 8, 2011)

-2011       Speaker, McKnight Brain Institute/Dept. Neuroscience Seminar: “TBI Biomarkers: from Bench to Bedside and Back”. Sept. 23, 2011 (Gainesville, FL, USA)

-2012         Speaker, World Congress on Brain Injury 2012, Edinburgh, 3/12/2012

-2012         Speaker, Keystone Conference on Chronic Traumatic Encephalopathy 2/26-3/2/2012

-2012       Speaker, 2hd Annual Biomarkers in Diagnostics and Therapeutics. Singapore, April 25-26, 2012

-2012         Speaker, 3rd Internatl. Congress of the Asica-Oceania Neurotrauma Soceity In Conjunction with Annual Internatl. Congress of the Academy of Multidisciplinary Neurotraumatology (AMN) May 13-15,2012

-2012       Sci. Program Chair, National Neurotrauma Society Symposium, Phoenix, July 12, 2012

-2012     Speaker, The International Neural Regeneration Symposium 2012, Shenyang, China, Sept. 22-25, 2012

-2013         Co-Chair/Speaker, SPIE Military Medicine Conference, Baltimore   April 29-May 3, 2013

-2013         Visiting Professor/Speaker, Wenzhou Medical University, Wenzhou Pharmaceutical Society and Changzhou Second Hospital, June 18-21, 2013

-2013         Speaker/ Sci. Program Com.   FASEB Summer Conference on Calpains (Vermont Academy – Saxtons River, VT) July 21-26, 2013,

-2013         Symposium Chair/Speaker, National Neurotrauma Symposium Gaylord Opryland Resorts in Nashville,    NNT-Nashville , August 4-7, 2013

-2013         Oration Speaker, 22nd Indian National Neurotrauma Society Conference, Guwahati, Assam -India. 22-25 Aug, 2013

-2014 Speaker, Association of Academic Physiatrists Annual Meeting 2014 lecture, Nashville, TN (2-27-2014)

-2014        Speaker, INTS 2014 –International Neurotrauma Society symposium (Budapest, Hungary Mar. 19-23, 2014

-2014         Speaker, Arrowhead TBI Conference, Washington, DC (April 16-17, 2014)

-2014         Speaker,/ Chairman, 3rd Annual Biomarkers in Diagnostics and Therapeutics (BDT). Singapore, Sept. 24-25, 2014

PUBLIC COMPETITIVE GRANTS

 

Funded & Completed (last 12 years)

-1999-2003 Principal Investigator, NIH-NINDS #R01 NS 40182 Subcontract “Calpain-Calpastatin Modulation of Traumatic Brain Injury”

-2000-2004 Principal Investigator NIH-NINDS #R01 NS 39091, Subcontract “Proteolytic Mechanisms of Traumatic Brain Injury”

-2001-2005 Co-PI Dept. of Defense (DoD-Army) Grant #DAMD17-01-1-0765, “Common mechanisms of neuronal cell death after exposure to diverse environmental insults: Implications for treatment” ($1,523,793) 3/1/2001-3/1/2005

-2003-2007 Co-PI Dept. of Defense (DoD-Army) Grant #DAMD17-03-1-0066 “Biochemical markers for brain injury: An integrated proteomics-based approach” 3/1/2003-3/1/2007

-2003-2004 Principal Investigator University of Florida Research Opportunity Fund, “Developing Novel Protease-targeted PET-visible “Inhibitor-ligands” to Image Neuronal Cell Damage Following Traumatic Brain Injury and Methamphetamine Exposure in Live Animals”: (9/2003 –9/2004).

-2004-2006 Principal Investigator Florida Alzheimer’s Center & Research Institute #2004A104B02 (00050836) “A biochemical linkage between traumatic brain injury and Alzheimer’s disease”; 8/1/04-8/1/06

-2004-2005 Co- Investigator, NIH-NINDS #1R43NS051039-01 (MW Oli, PI) “Novel Biomarkers for Stroke Injury” 6/8/2004 – 11/30/2005.

-2004-2009 Principal Investigator (from 2007) Dept of Defense (Army) , “Clinical Validation of Biochemical Markers of Brain Injury” (G. Robinson, PI, 2004-2007) Award# USA MRMC DAMD17-03-1-0772; Proposal 03031002

-2005-2007 Principal Investigator, Daimonion Diagnostics LLC. #Project# 2878 “Biomarker Characterization for traumatic Brain Injury (1/2005 –1/2007)

-2006-2008 Co-PI, DoD-Navy: #N00014-06-1-1029 “Biomarkers for Blast Induced Brain Injury”, 08/07/2006-08/06/2008

-2006-2008 Principal Investigator, LynnTech Inc. (DoD-Army STTR grant-University Subaward) #0064805-67224; “Biomarker Tools Characterization to Support Development and validation of Hand-Held Brain Injury Biomarker Device” 10/1/2006 – 8/31/2008

-2008-09 CO-PI (PI Dr. Y. Su) “Side-Stream Tobacco Smoke and Nitric Oxide Modification of Calpains in Airway Epithelial Repair” (UF08072) FAMRI proposal 00066256

-2007-2010 Principal Investigator NIH-NINDS #2R44NS048685-02 (SBIR), “Development of Novel Biomarkers for Traumatic Brain Injury” 9-1-07 to 8-31-10

-2007-2009 Co-PI,   NINDS-NIH, (1R21NS052322-01A1).(M.C. Liu, P.I.) “Proteolytic Mechanisms of Axonal and Dendritic Damage

-2005-2009 Principal Investigator, NINDS-NIH, R01 NS049175-01 A1 “Biochemical Basis of Axonal & Myelin Injury in Head Trauma” 5/1/2005- 5/1/2009

-2006-2009   Principal Investigator, Flight Attendant Medical Research Institute (FAMRI) Award # 052312 “Second Hand Smoke-Induced Heart and Brain Injury”” (4-1-2006 to 4-1-2009)

-2008-2009 Principal Investigator, Office of Naval Research ; # N00014-08-1-0911 Analytical and Regulatory Specifications for a Hand Held Device to Diagnose Traumatic Brain Injury, 9-1-2008 to 8-30-2009

-2007-2010, Principal Investigator, Florida State Center for Nano-Bio Sensors (CNBS)” Center of Excellence Grant Project#2- Traumatic Brain Injury Nanosensor (7-1-2007 to 6-30-2010)

2009 – 2011 PI (Consortium), USAMRAA DRMRP;   #304169-1.00-63083; (PI S. Ahlers, Office Naval Res.) Neuroimaging of biomarkers for combat relevant traumatic brain injury; 9/1/09-8/30/2011.

            -PET-ligand based imaging of calpain, caspase pathways, hypoxia and neutrophil activation following TBI and overpressure brain injury in rats.

-2008-2011 Co-PI,   DoD (Army Med Res.) #PT075454-NEW-00350671 (S. Svetlov, PI) Pathological Fingerprints, Systems Biology and Biomarkers of Blast Brain Injury. 4/1/2008 – 3/30/2011.

-2007-2011 Co-PI DoD-Army PRMRP# PR064667 (R.L. Hayes, PI) “Neuroproteomic and Biomarker Discovery for Penetrating Ballistic Brain Injury”. 3-1-2007 to 2-28-2011

-2009 – 2011 Co-PI (PI Stephen Larner) – DoD Deployment Related Medical Research Program (DRMRP) “Drug-Encapsulated Immunonanoparticles, Neuron-Targeted Delivery System”; Hypothesis Development Award (7-2009 – 7-2011 )

-2009-2011. Co-Principal Investigator Biomarkers: Evaluating and Treating Acute and Chronic TBI (PI Amy Wagner, U Pittsburgh). Dept of Defense W81XWH-07-1-070

-2007-2011 Co- PI (NINDS-NIH, R01-NS052831-01 R.L. Hayes, PI) “Unfolded Protein Response in Traumatic Brain Injury ”   1-1-2007 to 1-31-2012

-2005 –2011 Co-Investigator, Dept of Defense (Army) , (R. Hayes, PI) “BANDITS: Biomarkers of brain injury: magnitude, secondary insults & outcome” DoD W81XWH-06-1-0517.

-2006-2012 Co- PI , NINDS-NIH, R01-NS052831-01 (R.L. Hayes/ S. Robicsek, PI) “Clinical Biomarkers of Traumatic Brain Injury ” (9/1/2006-12/31/2012)

-2010-2012 Site Co-Investigator (Papa PI, ORMC ) NIH R01 NS057676 Biomarkers in mild moderate TBI

-2010-2012 Principal-Investigator DoD DMRDP Advanced Technology Development Award # DM090827 DoD W81XWH-11-2-0002 “An Innovative Theranostic Approach to TBI Drug Development: TBI Biomarkers-Guided Novel Calpain Protease Inhibitor as Neuroprotectant with Druggable Properties”.   10/1/10 – 10-31-2013

-2009-2013 Site Principal Investigator NIH 5 R01 HL095141-17 (PI W. Baumgartner, Johns Hopkins Univ.) Excitotoxicity in Circulatory Arrest Brain Injury. 3/1/09-2/28/2013

-2008-2013   Site Co-Investigator (G. Kamimori, WRAIR) Dept of Defense (Army Grant number W8IXWH-09-20055) “The new Zealand Breacher Biomarker study

-2013 Principal Investigator, Project 1 Systems Biomarkers for traumatic brain injury; Translation form animal models to human.   BSCIRFT 1/1/2013 – 12/31/2013

-2013-14 Principal Investigator,   Florida State/MBI   grant. Project # 91466       Bath salt effects on brain inflammation and perturbation, Funding Period 8/2013 – 7/2014

Funded & Current

-2010-2013 Principal Investigator . DoD W81XWH-10-1-0930 Dept of Defense for CDMRP-Concept Award (PH/TBI) # PT090850. Fibrin Matrix supported Mesenchymal Stem Cells Treatment for Traumatic brain Injury. Funding Period 9/27/10 – 12/26/2012 (no cost-extension)

-2011-2013 Site Principal Investigator (PI R. Rubenstein). Dept of Defense DRMRP Basic Research Grant # DM102153   DoD W81XWH-11-2-0069 subaward 56835 Dual Target-Based Neuroprotection Approach To Treat TBI.

            Funding Period 04/01/2012- 12/31/2014 (no cost extension)

            Aims: Studying the dual neuroprotective effects of cellular prion protein and calpain protease inhibition against traumatic brain injury in animal models.

-2010-2015 Site Co-Principal Investigator DoD W81XWH-10-1-0623 Subcontract 0011973 w/ Univ. Pittsburgh (Pat Kochanek) Operation Brain Trauma Therapy Funding Period 9/30/10-10/29/2015

            Aims: Studying experimental drugs in various model of TBI in neuroprotection, functional improvement and biomarker reduction

-2012-2015 Principal Investigator,-Partnering DOD (W81XWH-12-1-0277) CDMRP-SCI11026P1 Spinal Cord Injury Research Award (Other Partnering PI: Dalton Dietrich) TITLE: Spinal cord injury – protein biomarkers. FUNDING PERIOD 9/1.2012 – 8/30/2015

        Aims: Studying biomarker candidates in animal models and human spinal cord injury.

2013 Co-Principal Investigator (PI Prof. Andrew Maas, Universitair Ziekenhuis Antwerpen). Collaborative European NeuroTrauma Effectiveness Research in TBI (CENTER-TBI) European Union, FP7-HEALTH-2013-INNOVATION-1 Consortium grant,   12/1/2013 – 11/30/2018.

          Aims: Multi-centers study of clinical practice, management and diagnostic and prognostic tools of TBI in European countries.

-2013 – 2019 Co- Investigator (PI Geoff Manley, UCSF) Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK TBI). NIH-NINDS, NIH 1U01 NS086090-01; Funding Period Funding Period 8/1/2013 – 8/30/2019

          Aim:   The major goal of this project; to examine subacute and chronic biomarkers, imaging and other outcome in a multi-center cohort of human spectrum of severe, moderate and mild TBI subjects.

-2014   Principal Investigator (NIH-NINDS   R21 NS085455-01) “Elucidate Consequences of Autoimmune Response to Protease-modified GFAP in TBI” Funding Period 5/1/14-4/30/1

          Aim:   The major goal of this project is to examine in both mouse model if TB and human TBI the profile, prevalence and pathological role of anti-GFAP autoantibody development following brain injury,

-2014 ** 91684  Proj# 112310 Site PI BAA DOD-Army           W81XWH-BAA-14-1    To be Awarded, “SOFIA Ultra-sensitive TBI diagnosotic Test Platform” (PI R. Rubenstein)

-2014   **92492   Proj# 113761 Site PI To Be AWARDED    DOD-CDMRPW81XWH-13-PHTBI-TED mmTBI-Endpoint  na      13-Feb-14            “TBI Endpoints Development (TED)” (PI G. Manley, UCSF)

-2014   90359        Proj# 109917      Site PI Submitted 3-14  DOD       OBTT-“extended (PI P. Kochanek, Univ. Pittsburgh) To be Awarded

MANUSCRIPT REVIEWER

Science

  1. Biol. Chem.

J Neurochem.

Biochemistry;

Arch. Biochem. Biophys.;

Biotechniques;

Cell Calcium;

Mol. Cell. Biochem.;

Current Drug;

  1. Med. Chem.;

Europ. J. Biochem.;

Anal. Biochem.;

Biochim. Biophys. Acta;

Neurosci. Lett.

Neuroscience;

Cell Death & Differentiation;

Genomics;

Current Drugs,

  1. Mol. Neurosci.,
  2. Neursci. Res.;

Biochem. Pharmacol.;

Pediatric Res.;

Neuorbiol, Aging.;

Stroke;

Neuropharmacology,

Arch. Biochem. Biophys.

Cellular and Molecular Life Sciences

FEBS Lett.

  1. of Neuroscience (2007)

Organic and Medicinal Chemistry Letter

NeuroSignals

European Journal of Neuroscience

Cellular and Molecular Life Sciences

J.Cell Physiol. (2004)

Laboratory Investigation (2004-06)

  1. Mol. Biology (2004)

Drug Discovery Today (2004)

Neuropharmacology (2005)

Arch. Biochem Biophys. (2005)

Current Medicinal Chemistry (2006)

Experimental Brain Research (2006)

Journal of Ocular Pharmacology and Therapeutics (2006)

  1. pathology (2006)

Exp. Brain Res. (2006)

Exp. Neurology (2006)

Cell Biology and Toxicology (2006)

Expt. Cell Res. (2006)

Medical Science Monitor (2006)

  1. Biol. Chem. (2006)

International Journal of Medical Sciences (2007)

NEUROPSYCHOPHARMACOLOGY (2007)

Laboratory Investigation (2007)

Drug Discovery Today (2007)

Neuropharmacology

Arch. Biochem Biophys.

Expert Opinion on Therapeutic Targets (EOTT) (2008-)

Brain Research (2007-)

  1. of Neuroscience (2007-)
  2. Neurochem. (2005-)
  3. Neurotrauma (2002-pres.)

Expert Opinion on Therap.Patents (2007)

Pain (2007)

PLoS One (2007)

Proteomics – Clinical Applications (2008-)

GRANT REVIEWER

-1998             Canterbury Medical Research Foundation, New Zealand

-1998             The Wellcome Trust (Neuroscience), UK

-1999             Spinal Cord Research Foundation, Washington, D.C.

-2000             Spinal Cord Research Foundation, Washington, D.C.

-2000             Israel Science Foundation, Jerusalem, Israel

-2004             NIH-NICHD (National Institute of Child Health and Human Development) review session- ad hoc

-2004            National Science Foundation (NSF) grant reviewer

-2004             NIH-National Institute of Aging study session: “Proteomics in Aging” (July 14, 2004)

-2004             NIH-Neuro-engineering Committee – ad hoc grant reviewer (Aug 27, 2004)

-2004            NIH-NIMH review panel for exploratory research grants (R34) – ad hoc grant reviewer (Oct. 2004)

-2004             Neurological foundation of New Zealand, grant reviewer

-2005             UF Shands Cancer Center: grant reviewer

-2005             Australian National Health and Medical Research Council (NHMRC) Grant application Assessor

-2006             Alzheimer’s Association Grant reviewer

-2006             NCI proteomics Special Study Session (Silver Spring, MD) July 19-20, 2006

-2006             FAMRI Second Hand Smoke Grants Reviewer, Chantilly, Virginia (Nov. 6-7, 2006)

-2006-pres. Wings for Life – Spinal Cord Research Foundation, Member, Board of Reviewers

-2007-pres. Department of Defense USAMRMC TATRC grant application Reviewer (administrated by American Institute of Biological Sciences (AIBS).

-2007-pres. NIH-NIAAA SBIR Study Session, NINDS R21 study session

-2007-pres. NSF SBIR Review Panel (Aug. 6, 2007)

-2007-09       NIH Study sessions (Brain Injury and Neurovascular Pathologies (BDCN-L))+BINP ad hoc Reviewer

-2008             ad hoc Reviewer , NIH-NIDA Proteomic Center Grant

-2008             Reviewer, Ireland Science Foundation

-2008             ad hoc Reviewer, NIH-SBIR study session (ETTN)

-2008             Reviewer, DoD DRMRP-program 2008 (PHTBI-1 panel)

-2009             Reviewer (NIH/NIGMS) – Grant Opportunity (GO) grants

-2009-pres.   Standing Full Member, NIH BINP (Brain Injury and Neurovascular Pathologies) Study Session (10-2009 – pres.)

-2009             Reviewer, U.S.-Israel Binational Science Foundation

-2009-pres. CDMRP Reviewer

-2012 – pres. Member, VA RRDB1 Grant Review Panel

2012               Reviewer, French Research Agency

2012               Grant Reviewer, Canadian Institutes of Health Research

TEACHING

Course work

-1999-2002      Co-organizer and Lecturer, Course# Pharm 503, “Industrial Pharmacology- An overview of the pathway from drug target identification to clinical application”, Dept. Pharmacology, Univ. Michigan

-2004-08; 2009-10             Lecturer, Functional Genomic Applications in Pharmacology & Toxicology Course# GMA-7593 (Univ. Florida)

-2005                 CME credit course on BIOCHEMICAL MARKERS FOR BRAIN DAMAGE SEPTEMBER 8-10, 2005, Boothbay Harbor, Maine

-2007-08           Lecturer, Proteomics: Theory and Practice. Course# BOT 6935 (Univ. Florida)

-2009-10           Lecturer, Biophysical Techniques in Proteomics and Protein Science Course# BCH 6107 (Univ. Florida)

Junior Faculty / Postdoctoral Fellows mentored

Dr. Anu Waghray, Res. Assist Professor                                 1/2002 – 2/2005

Univ. Florida, Dept. Neuroscience                                            (last post – Walter Reed Army Inst. Res.)

Dr. Stan Svetlov, Res. Assist Professor                                    1/2004- 4/2008

Univ. Florida, Dept. Neuroscience                                            (now at Banyan Biomarkers, Inc)

Dr. Andrew Ottens, Res. Assist Professor                             2/2004 – 5/2008

Univ. Florida, Dept. Neuroscience                                            (now at Virginia Commonwealth Univ.)

Dr. Shi Peng, Res. Assist Professor                                           12/2011 – pres.

Postdoctoral Fellows mentored

Dr. Iradj Hajimohammadreza                                                      6/1993 – 7/1995

Parke-Davis Pharmaceutical Research                                   (now At Pfizer Inc., UK)

Dr. Rand Posmantur,                                                                      5/1996 – 3/1998

Parke-Davis Pharmaceutical Research                                   (now at Amgen, CA)

Dr. Neeta Mukerjee                                                                       5/1999 – 5/2000

Parke-Davis Pharmaceutical Research

Dr. Anu Waghray, postdoc Fellow                                             9/2001 – 6/2002

Pfizer Global R&D (Ann Arbor Res. Laboratories                                 (now at Univ. Maryland)

Dr. William Haskins, Postdoc. Fellow                                        9/2002 – 8/2003

Univ. Florida, Dept. Neuroscience                                            (now at Assist Prof. at Univ. Texas )

Dr. Andrew Ottens, Postdoc. Fellow                                       2/2003 – Present

Univ. Florida, Dept. Neuroscience                            (now Assist Prof at Virginia Commonwealth Univ.)

Dr. Stephen F. Larner, Postdoc. Fellow                                   6/2005 – Present

Univ. Florida, Dept. Neuroscience                                            (now at Banyan Biomarkers, Inc.)

Dr. Kai Qiu, Postdoc. Fellow                                                         9/2005 – 8/2006

Univ. Florida, Dept. Psychiatry                                                   (now at Univ. Florida-Dept. Neurosci.)

Dr. Joy Guingab, Postdoc Assoc.                                                                3/2009 – 2/2010

Univ. Florida, Dept. Psychiatry                                                   (now at Banyan Biomarkers, Inc.)

MS/Ph.D. Student Mentored

Dr. Kim McGinnis, Ph.D. prog.                                                   4/1996-6/1999 (graduated w PhD)

Dept. Pharmacology                                                                       Attorney, GLAD Organization, MA

Univ. of Michigan School of Medicine

Dr. Yanghae Park, PhD Program                                                 5/1998 – 11/2003 (graduated w PhD)

Dept. Pharmacology

Univ. of Michigan School of Medicine                                    (now at SK Chemicals, Seoul)

Stephen Larner,               IDP PhD student                               9/2000 – 8/2004 (graduated w PhD)

Univ. Florida, Dept. Neuroscience

Matt Warren, MD/PhD student                                                 9/2002 – 7/2006 (MD-PhD awarded)

Univ. Florida College of Medicine

Firas Kobeissy, PhD Student                                                        9/2002 – 6/2007 (PhD awarded)

Univ. Florida Inter-Disciplinary Program                                 (graduated w PhD, now at Dept. Psychiatry-UF)

-2005 Recipient of First place 2005 Alec Courtelis Awards for graduate studies. UF International Center

-2006 First Prize, Research Grant-in-aid – Robinson Endowment of the Tallahassee Memorial Hospital Foundation 6-1-2006

-2007 recipient of the UF Outstanding International Student Award

-2007 Excellence in Medical Education Award

Zhiqun Zhang, PhD Student                                                        9/2003 – 12/2007 (PhD awarded)

Univ. Florida Inter-Disciplinary Program                 (graduated w PhD, now at Univ. Florida)

-2006 Recipient of travel award, National Institute of Mental Health (NIMH) Division of Intramural Research Programs Pre-doctoral Research Festival 5-2006

-2006Honorable Mention, Research Grant-in-aid – Robinson Endowment of the Tallahassee Memorial Hospital Foundation 6-1-2006

-2006 Awarded Graduate Fellowships for Outstanding Research 2006, UF IDP program

 

Shankar Sadasivan, PhD Student                                                               9/2004 – 5/2008 (PhD awarded)

Univ. Florida Inter-Disciplinary Program   (graduated w PhD, now at St. Jude Res. Center, Memphis, TN)

-2005 First Place, Research Grant-in-aid – Robinson Endowment of the Tallahassee Memorial Hospital Foundation 6-1-2005

-2007 Recipient of the UF Outstanding International Student Award

Ahmed Moghieb, PhD                                                   9/2008 – 5/2014. (PhD awarded)

Ph.D. Candidate Analytical Chemistry/Proteomics), Univ. Florida Dept. of Chemistry (Co-mentor Dr. R. Yost)

Manasi Mangaonkar, Masters Degree                    92010 – 8/2013 (MS awarded)

PhD Student                    9/2013 – pres

Masters Degree (Analytical Chemistry/Proteomics) awarded (June 2012), Univ. Florida Dept. Chemistry

PhD Candidate (6/2012 – pres.) (Co-Mentor Dr. David Powell).

Rachna H. Manek, Master Student                                          9/2012 – pres.

Master Candidate (Translational Biotechnology), Univ. Florida, Dept. Psychiatry

Ph.D. Thesis Committee Member

Dr. Tao Lu, Graduated with Ph.D                                               9/1999 – 8/2001

Molecular & Cell Biology Program (Mentor: Dr. Ronald Mellgren)

Medical College of Ohio

Ms. L’Aurella Johnson, PhD Degree                                                         9/2001 – 8/2002

Dept. Pharmacology (Mentor: Dr. Margaret Gnegy)

Univ. of Michigan School of Medicine

Dr. Xinhua Huang, PhD Degree                                                                  7/2001 – 5/2003 (graduated w PhD)

Molecular & Cell Biology Program

Medical College of Ohio (Mentor: Dr. Ronald Mellgren)

Ms. Rebecca Ellis, PhD Degree                                                                   9/2000 – 9/2004 (graduated w PhD)

Univ. Florida, Dept. Neuroscience (Mentor: Dr. Douglas Andersen)

Clair Ringger, PhD Degree                                                                            9/2000 – 9/2004 (graduated w PhD)

Univ. Florida, Dept. Neuroscience (Mentor: Dr. Ronald Hayes)

2nd Prize Research Grant-in-aid – Robinson Endowment of the Tallahassee Memorial Hospital Foundation 6-1-2006

Eric Johnson, PhD Degree                                                                            9/2001 – 9/2005 (graduated w PhD)

Univ. Florida, Dept. Neuroscience (Mentor: Dr. Ronald Hayes)

Linda Lee, PhD Degree                                                                                  9/2004 – Present

Univ. Florida, Dept. Psychiatry (Mentor: Dr. Mark Lewis)

Andrew T. N. Tebbenkamp, PhD Degree                                                               9, 2006- 9-2008

Univ. Florida, Dept. Neuroscience (Mentor: Dr. David Borchelt)

Ph.D. Thesis External Examiner

Ms. Yewlan Wangigasekara                                                         5/2002 (graduated w PhD)

Faculty of Pharmacy, Univ. of Sydney

Mr. Carlos Alberto Ayala-Grosso                                                               1/2004 (graduated w PhD)

Dept. Pharmacol. Therapeutics, McGill University

Eugene Park, PhD candidate                                                                       1/2007

University of Toronto

 

NON-SCIENTIFIC SPEAKING ENGAGEMENT

March 12, 1998   “How to Do Academia-Like Research in Industry and Get Paid by Industry Scale” The Univ. Alabama at Birmingham Industry Roundtable, Birmingham, Alabama.

Jan 20, 1999   “Research Opportunity in Pharmaceutical Industry”, Undergraduate Research Opportunity Program, Univ. Michigan, Ann Arbor, Michigan

June 15, 1999   “Doing Basic Science Research At Parke-Davis”, Career Development Committee Noontime Seminar Series, Parke-Davis Pharmaceutical Research, Ann Arbor, MI.

Feb 18, 2005       “Academia, Big Pharmaceutical or Biotechnology Companies” Interdisciplinary Program of Gradate Students. , Gainesville, Florida.

Oct. 15, 2011      Speaker, Office of Licensing Technology Small Business Grants (SBIR) workshop, University of Florida, Gainesville, FL

Nov. 7-8, 2011   Panelist, The Business of Life Science Symposium, Florida State University, Tallahassee, FL

April 24, 2014 “Big Pharma, Biotechnology or Academia “ Partnering with Industry on Sponsored Research Workshop   (Gainesville, FL)

PUBLICATIONS

Edited Books

-a. Wang K.K.W. and Yuen, P.-w. (Eds.) (1999) “Calpain: The Pharmacology and Toxicology of Calcium-Dependent Protease”. Taylor and Francis, PA; 22 Chapters, 441 pages; 17 Jun 1999 | ISBN-10: 1560327138 | ISBN-13: 978-1560327134

-b. Ottens, A.K. and Wang, K.K.W. (Eds.) (2009) “Neuroproteomics Methods and Protocols”. In SERIES: Methods in Molecular Biology , Vol. 566 Springer Protocols, Humana Press, Dordrecht; August 9, 2009; 20 chapters, pp. 322 . ISBN-10: 1934115843 | ISBN-13: 978-1934115848

-c. Dambinova. S. Hayes, R.L., Wang, K.K.W. (Editors) (2012) “Biomarkers for Traumatic Brain Injury” Royal Society of Chemistry May 16, 2012 | ISBN-10: 1849733899 | ISBN-13: 978-1849733892

-d. Wang, K.K.W. , Zhang, Z., Kobeissy, F.H., (Editors) (2014) “Biomarkers of Brain Injury and Neurological Disorders” CRC Press, August 30, 2014; ISBN-13: 978-1482239829 ISBN-10: 1482239825

Original Articles, Invited Reviews

K Wang Pub. by PubMed

-001.      Wang, K.K.W., Villalobo, A. and Roufogalis, B.D. (1988) Activation of the Ca2+-ATPase of human erythrocyte membrane by an endogenous Ca2+-dependent neutral protease. Arch. Biochem. Biophys. 260, 696-704.

-002.      Olorunsogo, O.O., Villalobo, A., Wang, K.K.W. and Roufogalis, B.D. (1988) The effect of calmodulin on the interaction of carbodiimides with the purified human erythrocyte (Ca2+ +Mg2+)-ATPase. Biochem. Biophys. Acta 945, 33-40.

-003.      Wang, K.K.W., Roufogalis, B.D. and Villalobo, A. (1988) Further characterization of the calpain-mediated proteolysis of the human erythrocyte plasma membrane Ca2+ ATPase. Arch. Biochem. Biophys. 267, 317-327.

-004.      Wang, K.K.W., Roufogalis, B.D. and Villalobo, A. (1989) Calpain I activated Ca2+ transport by the human erythrocyte plasma membrane calcium pump In: Calcium Binding Proteins in Normal and Transformed Cells (Lawson, D.E.M. and Pochet, R., eds.) Plenum Publishing Co., pp. 171-176. (Advances in experimental medicine and biology 02/1990; 269:175-80.

-005.  Wang, K.K.W., Villalobo, A. and Roufogalis, B.D. (1989) Calmodulin-binding proteins as calpain substrates. (review) Biochem. J. 262, 693-706.

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-014.  Wang, K.K.W., Villalobo, A. and Roufogalis (1992) The plasma membrane calcium pump: a multiregulated transporter. (invited review) Trends Cell Biol. 2, 46-52.

-015. Kuo, T.H., Tsang, W., Wang, K.K.W. and Carlock, L. (1992) Simultaneous reduction of the sarcolemmal and SR calcium ATPase activities and gene expression in cardiomyopathic hamster. Biochim. Biophys. Acta 1138, 343-349.

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-017.  Buroker Kilgore, M. and Wang, K.K.W. (1993) A Coomassie brilliant blue G250-based colorimetric assay for measuring activity of calpain and other proteases. Anal. Biochem. 208, 387-392.

-018.  Elivira, M., Diez, J.A, Wang, K.K.W., Villalobo, A. (1993) Phosphorylation of connexin-32 by protein kinase C prevents its proteolysis by calpain I. J. Biol. Chem. 268, 14294-14300.

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-022.  Elvira, M., Wang, K.K.W. and Villalobo, A. (1994) Phosphorylated and non-phosphorylated connexin-32 molecules in gap junction plaques are protected against calpain proteolysis after protein kinase C-phosphorylation. Biochem. Soc. Trans. 22, 793-796.

-023. De Jongh K., Colvin, A.A., Wang, K.K.W. and Catterall, W.A. (1994) Differential Proteolysis of the full-length form of the L-type calcium channel α1 subunit by calpain. J. Neurochem. 63, 1558-1564.

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-026.  Posner, A., Raser, K. and Wang, K.K.W. (1995) Aurintricarboxylic acid is an inhibitor of µ -calpain and m-calpain. Biochem. Mol. Biol. Int. 36, 291-299.

-027.  Watson, P.H., Mortimer, S.T., Wang, K.K.W., Croall, D.E. and Hanley, D.A. (1995) Calcium activated proteases in the bovine parathyroid gland: potential role in degradation of parathyroid hormone to peptide fragments. J. Molecular Endocrinology. 15, 61-71.

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-029.          Raser, K.J., Buroker-Kilgore, M. and Wang, K.K.W. (1996) Binding and aggregation of human mu-calpain by terbium ion.. Biochim. Biophys. Acta 1292, 9-14.

-030.  Wang, K.K.W., Posner, A. and Hajimohammadreza, I. (1996) Improved method of total protein extraction from cultured cells for use in protein electrophoresis and Western blotting. Biotechniques, 20, 662-668.

-031.  Wang, K.K.W., Posner, A., Raser, K.J., Buroker-Kilgore, M., Probert, A.W., Marcoux, F.W., Hays, S.J., Lunney, E. and Hajimohammadreza, I., Yuen, P.-w. (1996) Α-mercaptoacrylic acid derivatives as novel selective calpain inhibitors. In: Intracellular Protein Catabolism (Ed. K. Suzuki, J.S. Bond), Plenum Publishing. 95-102.

-032.  Wang, K.K.W., Nath, R., Posner, A., Raser, K.J., Buroker-Kilgore, M., Ye, Q., Takano, E., Hatanaka, M., Maki, M., Marcoux, F.W., Caner, H., Collins, J.L., Fergus, A., Lee, K.S., Lunney, E.A., Hays, S.J. and Yuen, P.-w. (1996) An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable calpain inhibitor and is neuroprotective.. Proc. Natl. Acad. Sci. 93, 6687-6692.

-033Wang, K.K.W., Hajimohammadreza, I., Raser, K.J. and Nath, R. (1996) Maitotoxin induces calpain activation in SH-SY5Y neuroblastoma cells and cerebrocortical cultures. Arch. Biochem. Biophys. 331, 208-214.

-034. Hell, J.W., Westenbroek, R.E., Breeze, L.J., Wang, K.K.W., Chavkin, C. and Catterall, W.A. (1996) NMDA receptor-induced proteolytic conversion of postsynaptic class C L-type calcium channels in hippocampal neurons. Proc. Natl. Acad. Sci. 93, 3362-3367.

-035.  Vartanian, M.G., Cordon, J.J., Kupina, N.C., Schielke, G., Posner, A., Raser, K.J., Wang, K.K.W. and Taylor, C.P. (1996) Phenytoin pretreatment prevents hypoxic-ischemic brain damage in neonatal rats, Develop. Brain Res. 95, 169-175.

-036.  Edelstein, C.L., Yaqoob, M.M., Akhunaizi, A.M., Gengaro, P.E., Nemenoff, R.A., Wang, K.K.W., Schrier, R.W. (1996) Modulation of hypoxia-induced calpain activity in rat renal proximal tubules. Kidney Int. 50, 1150-1157.

-037.  Yuen, P.-w. and Wang, K.K.W. (1996) Therapeutic potential of calpain inhibitors in neurodegenerative disorders. Exp. Opin. Invest. Drugs 5, 1291-1304.

-038.  Nath, R., Raser, K.J., Stafford, D., Hajimohammadreza, I., Posner, A., Allen, H., Talanian, R.V., Yuen, P.-W., Gilbertsen, R.B. and Wang, K.K.W. (1996) Non-erythroid alpha-spectrin breakdown by calpain and interleukin 1 beta-converting-enzyme-like protease(s) in apoptotic cells: contributory roles of both protease families in neuronal apoptosis.. Biochem. J. 319, 683-690.

-039.  Nath, R., Raser, K.J., McGinnis, K., Stafford, D. and Wang, K.K.W. (1996) Effects of Calpain and ICE-like Protease Inhibitors on Neuronal Apoptosis. NeuroReport 8, 249-256.

-040.  Wang, K.K.W. and Yuen, P.-w. (1997) Development and Therapeutic Potential of Calpain Inhibitors. Adv. Pharmacol. 37, 117-152.

-041.  Gilbertsen, R.B., Posmantur, R., Nath, R., Wang, K.K.W. (1997) Apoptotic death induced in MOLT-4 T-lymphoblasts by purine nucleoside phosphorylase inhibition. Inflamm. Res. 46, S151-S152.

-042.  Posmantur, R., McGinnis, Nadimpalli, R., Gilbertsen, R. and Wang, K.K.W. (1997) Characterization of CPP32-like protease activity following apoptotic challenge in SH-SY5Y neuroblastoma cells. J. Neurochem. 68, 2328-2337.

-043.  Hajimohammadreza, I., Nath, R., Raser, K.J., Nadimpalli, R. and Wang, K.K.W. (1997) Proteolysis of Neuronal nitric oxide synthase and calmodulin-dependent protein kinase IIalpha undergo neurotoxin-induced proteolysis. J. Neurochem. 69, 1006-1013.

-044.  Lin, G.-d., Chattopadhyay, D., Maki, M., Wang, K.K.W., Carson, M., Takana, E., Hatanaka, M., DeLucas, L.J., Narayana, S.V.L. (1997) Crystal structure of calcium bound domain VI of calpain at 1.9A resolution and its role in enzyme assembly and inhibitor binding. Nature Structure Biology 4, 539-547.

-045.  Posmantur, R., Wang, K.K.W., Nath, R., Gilbertsen, R., (1997) a purine nucleoside phosphorylase (PNP) inhibitor induces apoptosis via caspase-3 like protease activity in Molt-4 cells. Immunopharmacology 37, 231-244.

-046.  Nath, R., Hajimohammadreza, I. and Wang, K.K.W. (1997) Thapsigargin induces apoptosis in SH-SY5Y neuroblastoma cells and cerebrocortical cultures. Biochem. Mol. Biol. Int. 43, 197-205.

-047.  Waters, S.L., Sarang, S.S., Wang, K.K.W. and Schnellmann, R.G. (1998) Calpains mediate calcium and chloride influx during the late phase of cell injury. J. Pharmacol. Exp. Ther. 283, 1177-1184.

-048.  Zhao, X., Posmantur, R., Kampfl, A., Liu, S.J., Wang, K.K.W., Newcomb, J.K., Pike, B., Clifton, G.L. and Hayes, R.L. (1998) Subcellular localization and duration of µ -calpain and m-calpain activity following traumatic brain injury in the rat: A casein zymography study. J. Cereb. Blood Flow Metab., 18, 161-167.

-049.  Hays, S.J., Caprathe, B.W., Gilmore, J.L., Amin, N., Emmerlings, M.R., Michael, W., Nadimpalli, R., Nath, R., Stafford, D., Watson, D., Wang, K.K.W., Jaen, J.C. (1998) 2-Amino-4H-3,1-benzoxazin-4-ones as inhibitors of C1r serine protease. J. Med. Chem. 41, 1060-1067.

-050.  Yuen, P.-w. and Wang, K.K.W. (1998) Calpain Inhibitors: Novel Neuroprotectants and Potential Anticataractic Agents. Drug of Future, 23 741-749.

-051.  Nath, R., Probert, A., Jr., McGinnis, K.M., Wang, K.K.W. (1998) Evidence for Activation of Caspase-3-like Protease in Excitotoxins- and Hypoxia/hypoglycemia-Injured Neurons. J. Neurochem. 71, 186-195.

-052.  Wang, K.K.W., Posmantur, R., Nath, R., McGinnis, K., Whitton, M., Talanian, R.V., Glantz, S., Morrow, J. (1998) Simultaneous Degradation of αII- and βII-Spectrin by Caspase 3 (CPP32) in Apoptotic Cells. J. Biol. Chem. 273, 22490-22497.

-053.  Hayes, R.L., Wang, K.K.W., Kampfl, A., Posmantur, R.M., Newcomb, J.K. and Clifton, G.L. (1998) The potential contribution of proteases to Neuronal damage. Drug News Perspect. 11, 215-222.

-054.  Pike, B.R., Zhao, X., Newcomb, J.K., Wang, K.K.W., Posmantur, R.M., Hayes, R.L. (1998) Temporal Relationships between de novo protein synthesis, calpain and caspase 3-like protease activation, and DNA Fragmentation during apoptosis in sept-hippocampal cultures. J. Neurosci. Res. 52, 505-520.

-055.  Zhao, X., Newcomb, J.K., Posmantur, R.M., Wang, K.K.W., Pike, B.R. and Hayes, R.L. (1998) pH dependency of µ -calpain and m-calpain activity assayed by casein zymography following traumatic brain injury in the rat. Neurosci. Lett. 247, 53-57.

-056.  McGinnis, K.M., Whitton, M., Gnegy, M.E., Wang, K.K.W. (1998) Calmodulin-dependent protein kinase IV differentially cleaved by caspase-3 and calpain in SH-SY5Y human neuroblastoma cells. J. Biol. Chem. 273, 19993-20000.

-057.  Wang, K.K.W., Posmantur, R., Nadimappli, R., Nath, R., Mohan, Nixon, R.   Talanian, R.V., Allen, H. (1998) Caspase-mediated Fragmentation of Calpain Inhibitor Protein Calpastatin during apoptosis. Arch. Biochem. Biophys. 356, 187-196.

-058.  Posmantur, R.M., Wang, K.K.W., Gilbertsen, R.B. (1998) Caspase-3 like activity is necessary for IL-2 release in Activated Jurkat T-cells. Exp. Cell Res. 244, 302-309.

-059.  Pike, B.R., Zhao, X., Newcomb, J.K., Posmantur, R.M., Wang, K.K.W., Hayes, R.L. (1998) Regional calpain and caspase-3 proteolysis of α-spectrin after traumatic brain injury. NeuroReport. 9, 2437-2442.

-060.  Plummer J.S., Cai, C., Hays, S.J., Gilmore, J.L., Emmerling, M.R., Michael, W., Narasimhan, L.S., Watson, M.D., Wang, K.K.W., Nath, R. and Jaen, J.C. (1999) Benzenesulfonamide derivatives of 2-substituted 4h-3,1-benzoxazin-4-ones and benzthiazin4-ones as inhibitors of complement c1r protease. Bioorg. Med. Chem. Lett. 9, 815-820.

-061.  Wang, K.K.W. (1999) Detection of proteolytic enzymes using protein substrates. In Proteolytic Enzymes -Tools and Targets (Springer Lab Manual) (Sterchi, E.E., Stocker, W. Eds.) Springer-Verlag, Heidelberg, Chapter 4, pp. 49-62.

-062.  Wang K.K.W. and Yuen, P.-w. (1999) Calpain Substrates, Assay Methods, regulation and Inhibitory agents. In Calpain: Pharmacology and Toxicology of a Calcium-dependent Cellular Protease (Eds. K. Wang, P. Yuen), Taylor and Francis, Chapter 5, pp 77-101.

-063.  Wang, K.K.W., Yuen, P.-w., Lee, K.S. (1999) Calpain in excitotoxicity, cerebral ischemia and neuronal apoptosis In Calpain: Pharmacology and Toxicology of a Calcium-dependent Cellular Protease (Eds. K. Wang, P. Yuen), Taylor and Francis, Chapter 9, pp 179-209.

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-066.  McGinnis, K.M., Wang, K.K.W., Gnegy, M.E. (1999) Alternations of extracellular calcium elicit selective modes of cell death and protease activation in SH-SY5Y human neuroblastoma cells. J. Neurochem. 72, 1853-1863.

-067.  Zhao, X., Pike, B.R., Newcomb, J.K., Wang, K.K.W., Posmantur, R.M. and Hayes, R.L. (1999) Maitotoxin induces calpain but not caspase-3 activation and necrotic cell death in primary septo-hippocampal cultures. Neurochem. Res. 24: 371-382.

-068.  McGinnis, K.M., Gnegy, M.E., Park, Y.H., Mukerjee, N., Wang, K.K.W. (1999) Pro-caspase-3 and poly(ADP)ribose polymerase(PARP) are calpain substrates. Biochem. Biophys. Res. Commun.263, 94-99.

-069.  Nath, R., Scott,, M., Nadimpalli, R., Gupta, R. and Wang, K.K.W. (1999) Activation of Apoptosis-linked Caspase(s) in NMDA-injured brains in Neonatal Rat. Neurochem. Int. 36, 119-126.

-070.  Wang, K.K.W. (1999) Caspases: A Drug Discovery Perspective. Curr.Opin. Drug Discovery Develop. 2, 519-527.

-071. Wang, K.K.W. (2000) Calpain and Caspase: Can You Tell the Difference. Trends Neurosci. 23, 20-26.

-072.  Nath, R., Huggins, M., McGinnis, K., Nadimpalli, D., Wang, K.K.W. (2000) Development and characterization of antibodies specific to caspase-3-produced αII-spectrin 120 kDa breakdown product: Marker for neuronal apoptosis. Neurochem. Int. 36, 351-361.

-073.  Zhao, X., Newcomb, J.K., Pike, B.R., Wang, K.K.W., d’Avella, D. and Hayes, R.L. (2000) Novel characteristics of glutamate-induced cell death in primary septohishippocampal cultures: Relationship to calpain and caspase-3 protease activation. J. Cereb. Blood Flow Metab. 20 (3) 550-562.

-074.  Buki A.; Okonkwo D.O; Wang K. K W; Povlishock John T (2000) Cytochrome c release and caspase activation in traumatic axonal injury. J. Neuroscience 20 (8), 2825-2834.

-075.  Mukerjee, N., McGinnis, K.M., Park, Y.H., Gnegy, M.E., Wang, K.K.W. (2000) Caspase-mediated proteolytic activation of calcineurin in thapsigargin-mediated apoptosis in SH-SY5Y neuroblastoma cells. Arch. Biochem. Biophys. 379 :337-343.

-076.  Nath, R., Davis, M. Probert, A.W., Kupina, N.C., Ren, X.D., Schielke, G.P. and Wang, K.K.W, (2000) Processing of cdk5 activator p35 to its truncated form (p25) by calpain in acutely injured neuronal cells. Biochem. Biophys. Res. Commun. 274, 16-21.

-077.  Zimmerman, U-J P., Boring, L., Pak, J.H., Mukerjee, N. and Wang, K.K.W. (2000) The calpain small subunit gene is essential: its inactivation results in embryonic lethality. IUBMB Life. 2000 Jul;50(1):63-68.

-078.  Huang, Y.H. Sun, Y. and Wang, K.K.W. (2001) Molecular cloning and characterization of a novel caspase-3 variant that attenuates apoptosis induced by proteasome inhibition.. Biochem. Biophys. Res. Commun. 283, 762-769.

-079.  Zhao X, Bausano B, Pike BR, Newcomb-Fernandez JK, Wang KKW, Shohami E, Ringger NC, DeFord SM, Anderson DK, Hayes RL. (2001) TNF-a Stimulates Caspase-3 Activation and Apoptotic Cell Death in Primary Septo-Hippocampal Cultures. J. Neurosci. Res. 64:121-131.

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-081.  Huang Y. and Wang, K.K. (2001) The calpain family and human disease. Trends in Molecular Medicine 7, 355-362.

-082.  Nath, R., McGinnis, K., Dutta, S., Shivers, B., Wang, K.K.W. (2001) Inhibition of p38 kinase mimics survival signal-linked protection against apoptosis in rat cerebellar granule neurons. Cell Mol. Biol. Lett. 6, 173-184.

-083.  Mukerjee, N., McGinnis, K.M., Gnegy, M.E., Wang, K.K.W. (2001) Caspase-mediated calcineurin activation contributes to IL-2 release during T-cell activation. Biochem. Biophys. Res. Commun. 285, 1192-1199.

-084.  Perez, A., Probert, A.W., Wang, K.K.W., Sharmeen, L. (2000) Evaluation of HIV-1 Tat induced neurotoxicity in rat cortical cell culture. J Neurovirol. 2001 Feb;7(1):1-10.

-085. Pike, B.R., Flint, J, Johnson, E., Glenn, C.C., Dutta, S., Wang, KKW and Hayes, R.L. (2001) Accumulation of Calpain-Cleaved Non-Erythroid αII-Spectrin in Cerebrospinal Fluid after Traumatic Brain Injury in Rats. J. Neurochem. 78, 1297-1306.

-086.  Beer R, Franz G, Krajewski S, Pike BR, Hayes RL, Reed JC, Wang KK, Klimmer C, Schmutzhard E, Poewe W, Kampfl A.(2001) Temporal and spatial profile of caspase 8 expression and proteolysis after experimental traumatic brain injury. J Neurochem. 78(4):862-873.

-087.  Zhao X, Bausano B, Pike BR, Newcomb-Fernandez JK, Wang KK, Shohami E, Ringger NC, DeFord SM, Anderson DK, Hayes RL. (2001) TNF-α stimulates caspase-3 activation and apoptotic cell death in primary septo-hippocampal cultures. J Neurosci Res. 64(2):121-131.

-088.  Newcomb-Fernandez, J.K., Zhao, X., Pike, B.R., Wang, K.K.W., Kampfl, A., Beer, R., Deford, SM. and Hayes, R.L. (2002) Concurrent assessment of calpain and caspase-3 activation after oxygen-glucose deprivation in primary septo-hippocampal cultures. J. Cereb. Blood Flow Metab. 21, 1281-1294.

-089. Kupina, N.C., Nath, R., Bernath, E.E. Inoue,J. Azuma, M. Yuen, P.-w. Wang K.K.W., and D. Hall, E.D. (2001) The Novel Calpain Inhibitor SJA6017 Improves Functional Recovery After Delayed Administration in a Mouse Model of Diffuse Head Injury. J. Neurtrauma. 18, 1229-1240.

-089a. Inoue J, Nakamura M, Cui YS, Sakai Y, Sakai O, Hill JR, Wang KK, Yuen PW. Structure-activity relationship study and drug profile of N-(4-fluorophenylsulfonyl)-L-valyl-L-leucinal (SJA6017) as a potent calpain inhibitor. J Med Chem. 2003 Feb 27;46(5):868-71.

-090.  Wang, K.K.W. (2002) Assaying proteases in cellular environments In: Current Protocols in Protein Science (Ed. J.E. Coligan, B. Dunn, H.L. Ploegh and D.W. Speicher) John Wilkey & Sons, Inc. New York. p.12. 21.1-21.12.14.

-091.  Wang, K.K.W. (2002) Therapeutic approaches with protease inhibitors in neurodegenerative and neurological diseases In: Role of Protease in the Pathology of Neurodegenerative Disease (N. Banik, A. Lajtha and Smith eds.), Kluwer Academic/Plenum Publishers, New York, Chapter 13. pp. 250-279.

-092.  Wang, K.K.W. (2002) Calpain and caspase in ischemic and traumatic brain injury. In New Concepts in Cerebral Ischemia. (Ed. Rick Lin) CRC press, Chapter 8 , pp. 181-200.

-093.  Bian, F., Nath, R., Vergara, G., Booher, R., Lipinski, W.J., Callahan, M.J., Pack, A., Sobocinski, G., Wang, K.K.W., Walker, L.C. (2002) Axonopathy, tau abnormalities, and dyskinesia, but no neurofibrillary tangles in p25-transgenic mice.. J. Com. Neurol. 446:257-266.

-094.  Dutta, S. Chiu, Y.C. Probert, A.W., Wang, K.K.W. (2002) Selective release of calpain produced alphalI-spectrin (alpha-fodrin) breakdown products by acute neuronal cell death.. Biol. Chem. May;383(5):785-791.

-095.  Huang, Y., Tan, M., Gosink, M., Wang, K.K.W. and Sun, Y. (2002) Histone Deacetylase 5 is not a p53 target gene, but its overexpression inhibits tumor cell growth and induces apoptosis. Cancer Res. 62, 2913-2922.

-096.  Tolentino,P.J. Michelle, S., DeFord, Lucia Notterpek, L.,Glenn,C.C. Pike, P.R. Kevin K. Wang, K.K.W. and Hayes, R.L. (2002) Upregulation of tissue-type transglutaminase after traumatic brain injury. J Neurochem. 80:579-588.

-097.  Franz G, Beer R, Intemann D, Krajewski S, Reed JC, Engelhardt K, Pike BR, Hayes RL, Wang KK, Schmutzhard E, Kampfl A. (2002) Temporal and spatial profile of bid cleavage after experimental traumatic brain injury. J Cereb Blood Flow Metab. 22:951-958.

-098.  Park, Y.H., Kantor, L., Wang, K.K.W., Gnegy, M.E. (2002) Repeated intermittent treatment with amphetamine induces neurite outgrowth in rat pheochromocytoma cells (PC12 cells). Brain Research 951, 43-52.

-099.  Kantor L, Park YH, Wang KK, Gnegy M. (2002) Enhanced amphetamine-mediated dopamine release develops in PC12 cells after repeated amphetamine treatment. Eur J Pharmacol. 2002 Sep 6;451(1):27-35.

-100.  Wang, K.K.W. (2003) Limiting Apoptosis in Neurodegeneration In: Handbook of Experimental Pharmacology; Volume – “CNS Neuroprotection” (F.W. Marcoux; D.W. Choi, Eds.) Springer-Verlag, Berlin, pp 37-64. (Chapter 2).

-101.  McGinnis, K.M., Gnegy, M.E. and Wang, K.K.W. (2003) Cytochrome C translocation does not lead to caspase activation in maitotoxin-treated SH-SY5Y human neuroblastoma cells. Neurochem. Int 42(6):517-523.

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-103. Inoue J, Nakamura M, Cui YS, Sakai Y, Sakai O, Hill JR, Wang KKW, Yuen PW. (2003) Structure-activity relationship study and drug profile of N-(4-fluorophenylsulfonyl)-L-valyl-L-leucinal (SJA6017) as a potent calpain inhibitor. J Med Chem. 2003 Feb 27;46(5):868-71.

-104. Park YH, Kantor L, Guptaroy B, Zhang M, Wang KK, Gnegy ME. (2003) Repeated amphetamine treatment induces neurite outgrowth and enhanced amphetamine-stimulated dopamine release in rat pheochromocytoma cells (PC12 cells) via a protein kinase C- and mitogen activated protein kinase-dependent mechanism.J Neurochem. 2003 Dec;87(6):1546-57.

-105   Todd B, Moore D, Deivanayagam CC, Lin GD, Chattopadhyay D, Maki M, Wang KKW, Narayana SV. (2003) A structural model for the inhibition of calpain by calpastatin: crystal structures of the native domain VI of calpain and its complexes with calpastatin peptide and a small molecule inhibitor. J Mol Biol. 2003 Apr 18;328(1):131-46.

-106. Pineda, J.A., Wang, K.K.W., Hayes, R.L. (2004) Biomarkers of Proteolytic Damage Following Traumatic Brain Injury. Brain Pathology, 14, 202-209.

-107. Larner, S.F., McKinsey, D.M., Torres, M., Pike, M. Hayes, R.L. and Wang, KKW. (2004) Upregulation of caspase-12 after traumatic brain injury in rats. J. Neurochem. 88(1): 78-90.

-108. Ellis, R.L., , Earnhardt, J.N., Hayes, R.L., Kevin K.W. Wang, K.K.W. and Anderson, D.K. (2004) Cathepsin B mRNA and protein expression following contusion spinal cord injury in rats. J. Neurochem. 88(3): 689-697.

-109. Wang, K.K.W., Ottens, A., Haskins, W.E., Liu, M.C., Denslow, N., Chen, S.S., Hayes, R.L. (2004) Neuroproteomic studies of traumatic brain injury. (in Special issue “Human brain Proteome” -L. A. Neuhold, Ed.): Int. Rev. Neurobiol. 61: 215-240.

-110. Ringger, N.C., Tolentino, P.J., McKinsey, D.M., Pike, B.R., Wang, K.K.W. and Hayes, R.L. (2004) Effects of injury severity on regional and temporal mRNA expression levels of calpains and caspases after TBI. J. Neurotrauma, 21, 829-841.

-112. Waghray, A., Wang, D., McKinsey, D.M., Hayes, R.L. and Wang, K.K.W. (2004) Molecular cloning and characterization of rat and human calpain-5. Biochem. Biophys. Res. Commun. 324, 46-51.

-113. Tolentino, P.J., Waghray , A., Wang, K.K.W., Hayes, R.L. (2004) Increased expression of tissue-type transglutaminase following middle cerebral artery occlusion in rats. J. Neurochem. 89, 1301-1307.

-114. Chen,S.S, Haskins, W.E., Zhang, ZQ, Denslow, N., A., Hayes, R.L. Wang, K.K.W. , Ottens, AK, (2007) Bioinformatics for Traumatic Brain Injury: Proteomic Data Mining In “Data Mining in Biomedicine” (Ed. Panos Pardalos , Boginski, V.L., Vazacopoulos, A.  Springer, pp. 1-26.

-115. Svetlov, S.I., Ignatova, T.N., Wang,K.K.W. Hayes, R.L., Kukekov, V.G. (2004) Growth and Clonal Expansion of Neural Stem/Progenitor Cells by Lysophosphatidic acid (LPA) in Mouse Neurospheres. J. Hematotherapy & Stem Cell Research, 13, 685-693.

-116. Johnson EA, Svetlov SI, Pike BR, Tolentino PJ, Shaw G, Wang KK, Hayes RL, Pineda JA. (2005) Cell-specific upregulation of survivin after experimental traumatic brain injury in rats. J Neurotrauma. 2004 Sep;21(9):1183-1195.

-117. Ellis, R.L., W. O’Steen, Hayes, R.L., Kevin K.W. Wang, K.K.W. and Anderson, D.K. (2005) Cellular localization and enzymatic activity of cathepsin B after spinal cord injury in the rat. Experimental Neurology May;193(1):19-28.

-118. Ringger, N.C., O’Steen, B.E., Brabham, J.G., Silver, X., Pineda, J., Wang, K.K.W. and Hayes, R.L. (2005) A novel marker for traumatic brain injury: CSF αII-spectrin breakdown product levels. J. Neurotrauma 21, 1443–1456.

-119. Haskins WE, Kobeissy FH, Wolper RA, Ottens AK, Kitlen JW, McClung SH, O’Steen BE, Chow MM, Pineda JA, Denslow ND, Hayes RL, (2005) Rapid Discovery of Putative Protein Biomarkers of Traumatic Brain Injury by Wang KKW. SDS-PAGE-Capillary Liquid Chromatography-Tandem Mass Spectrometry, J Neurotrauma 22(6): 629-644, 2005.

-120. Johnson, E.A. Svetlov, S., Wang, K.K.W. and Ronald L. Hayes, R.L and Pineda, J.A. (2005) “Cell-Specific DNA Fragmentation May Be Attenuated by a Survivin-Dependent Mechanism Following Traumatic Brain Injury in Rats”. Exp. Brain Res, 167(1):17-26.

 -121. Larner, S.F., McKinsey, D.M., Hayes, R.L., Wang, K.K.W. (2005) Caspase-7: Increased Expression and Activation Following Traumatic Brain Injury in Rats. J. Neurochem. 94(1):97-108.

-122. Bernath, E., Liu, M.C. Hayes, R.L. and Meegan, C., Wang, K.K.W. (2006) Elevation of Cytoskeletal Protein Breakdown in Aged Wistar Rat. Brains. Neurobiol of Aging 27(4), 624-632.

-123. Wang, K.K.W. Ottens, A., Liu, M.C., Lewis, S.B., Meegan, C., Oli, M.W., Tortella, F.C., Hayes, R.L., (2005) Proteomic identification of biomarkers of traumatic brain injury. Expert Reviews Proteomics 2(4):603-614.

-124. Ottens, A.K., Kobeissy, F.H., Wolper, R.A., Haskins, W.E., Hayes, R.L., Denslow, N.D., Wang, K.K.W. (2005) Combined Cationic and Anionic Ion-Exchange Liquid Chromatography Tandem Polyacrylimide Gel Electrophoresis Separation for Targeting Differential Expression in Proteomic Mixtures. Anal. Chem. 77, 4836-4845.

-125. Warren, M.W., Kobeissy, F.H., Hayes, R.L., Gold, M.S., Wang, K.K.W. (2005) Concurrent calpain and caspase-3 mediated proteolysis of αII-spectrin and tau in rat brain after methamphetamine exposure: A similar profile to traumatic brain injury. Life Sciences 78: 301-309.

-126. French JP, Quindry JC, Falk DJ, Staib JL, Lee Y, Wang K.K.W., Powers SK. (2006) Ischemia-reperfusion induced calpain activation and SERCA2a degradation are attenuated by exercise training and calpain inhibition. Am J Physiol Heart Circ Physiol. 290(1):H128-36.

-127. Johnson, E.A., Svetlov, S.I., Wang, K.K.W., Hayes, R.L., Pineda, J.A. (2005) Cell-specific DNA fragmentation may be attenuated by a survivin-dependent mechanism after traumatic brain injury in rats. Experimental Brain Research 167(1):17-26.

-128. Ottens AK, Kobeissy FH, Golden EC, Zhang Z, Haskins WE, Chen SS, Hayes RL, Wang KKW, Denslow ND. (2006) Neuroproteomics in neurotrauma. Mass Spectrm. Rev. 25:380-408.

-129. Kobeissy, F.H., Wang, K.K.W., Demetree, J.M., Ottens, A.K., Zheng, W.R., Warren, M., Gold, M.S. (2005) Club Drugs: They’re All the Rave: A Review of Use and Abuse: Effects of MDMA, Methamphetamine, and Gamma-Hydroxy-Butyrate (GHB) on Memory. Law Enforcement Executive Forum 5(5), 115-125.

-130. Zhang, Z.Q., Ottens, A.K., Larner, S.F., Kobeissy, F.H., Williams, M.L., Hayes, R.L., Wang, K.K.W. (2006) Rho-associated kinase inhibitor, Y-27632, induces robust and rapid neurite outgrowth in PC-12 cells. Cell Mol. Biol. Lett, 11, 15-32.

-131. Zhang, Z.Q., Kammerdiner, A.R.; Busygin, S.P., Ottens, A.K.; Larner, S.F.; Kobeissy, F.H.; Pardalos, P.M.; Hayes, R.L. Wang, K.K.W. (2007) Application of the Data Mining Techniques to the Systems Biology of Neuritogenesis. Optimization Methods and Software, Volume 22, pages 215 – 224

-132. Liu M.C., Akle, V., Zheng, W.R., Dave, J.R., Tortella, F.C., Hayes, R.L., Wang, K.K.W., (2006) Comparing calpain- and caspase-3-degradation patterns in traumatic brain injury by differential proteome analysis. Biochem. J. 394, 715-725.

-133. Larner, S.F., Hayes, R.L., Wang, K.K.W. (2006) Unfolded Protein Response after Neurotrauma (review). J. Neurotrauma. ;23(6):807-829.

-134. Sadasivan, S., Waghray, A., Larner, S.F., William A. Dunn, W.A. Jr., Hayes, R.L. and Wang, K.K.W. (2006).Amino Acid Starvation Induced Autophagic Cell Death in PC-12 Cells: Evidence for Activation of Caspase-3 but not Calpains. Apoptosis 11(9):1573-1582.

-135. Liu, M.C., Zheng, W.R., Kitlen, J.,, O’Steen, B., Flint, J. , Dave, J.R., Tortella F.C., Hayes, R.L., and Wang, K.K.W. (2006) Extensive myelin basic protein degradation in rat brain after traumatic brain injury. J. Neurochem. 98, 700-712.

-136. Glantz SB, Cianci CD, Iyer R, Pradhan D, Wang KK, Morrow JS.Sequential Degradation of betaII and alphaII Spectrin by Calpain in Glutamate or Maitotoxin-Stimulated Cells. Biochemistry. 2007 Jan 16;46(2):502-13.

-137. Aikman J., O’Steen B., Silver X., Torres R., Boslaugh S., Blackband S., Padgett K., Wang K.K. W., Hayes R.L., Pineda J. (2006) αII-Spectrin After Controlled Cortical Impact In The Immature Rat Brain. Dev. Neurosci. 2006;28(4-5):457-65.

-138. Warren, M.W., Kobeissy, F.H., Liu, M.C., Hayes, R.L., Gold, M.S., Wang, K.K.W (2006) Ecstasy Toxicity: A Comparison to Methamphetamine and Traumatic Brain Injury. J. Addict Disease, 25(4):115-123.

-139. Zhang, Z.Q., Ottens, A.K., Golden, E.C., Kobeissy, F.H., Liu, M.C., Hayes, R.L. and Wang, K.K.W. (2006) Using calmodulin-affinity capture to study the rat brain calmodulin binding proteome and its vulnerability to calpain and caspase proteolysis. Calcium Binding Prot. 1 (2) 125-134. Received Editorial Comment.

-140. Svetlov, S.I., Xiang, Y.W., Oli, M., Foley, D.P., Huang, G., Hayes, R.L., Ottens, A.K., Wang, K.K.W. (2006) Identification and preliminary validation of novel biomarkers of acute hepatic ischemia/reperfusion injury using dual-platform proteomic/degradomic approaches. Biomarkers, 11: 355-369.

-141. Kobeissy, F.H., Ottens, A.K., Zhang, Z.Q., Dave, J.R., Tortella F.C., Hayes, R.L. Wang, K.K.W. (2006) Novel differential neuroproteomics analysis of traumatic brain injury in rats.. Mol. Cell. Proteomics 5, Oct;5(10):1887-1898. (Cover page article, June 2006).

-142. Warren, MW. Zheng, W.R., Kobeissy , F., Liu, M.C.,, Hayes, R.L., Gold, Mark, M.C. Liu, and Wang, K.K.W. (2006) Calpain and caspase mediated proteolysis of αII-spectrin and tau in rat cerebrocortical neuron cultures after ecstasy (MDMA) or methamphetamine exposure Int. J. Neuropsypharm. 9, 1-11.

-143. Wang, K.K.W. , Larner, S.F., Robinson, G., Hayes, R.L. (2006) Neuroprotection Targets After Traumatic Brain Injury. Current Opinion in Neurology, 19:514–519.

-144. Larner, S.F., Hayes, R.L., Wang, K.K.W. (2009) Proteolytic Mechanisms of Cell Death in the Central Nervous System. In Handbook of Neurochemistry and Molecular Neurobiology. (Ed. Abel Lajtha) Vol. 24: Brain and Spinal Cord Trauma 240-279.

-145. Ottens, A.K., Kobeissy, F., Fuller, B.F., ., Liu, M.C., Oli, M.W., R.L. Hayes, Wang, K.K.W. (2007) Novel neuroproteomic approaches to studying traumatic brain injury. Prog. Brain Res. (Neurotruma) 161: 401-418.

-146. Pineda, J., Liu, M.C., Aikman, J., Akle, V., . Lewis, S., Wang, K.K.W., Robertson, C., Hayes, R.L. (2007) Clinical significance of αII-Spectrin Breakdown Products in CSF after Severe Traumatic Brain Injury in Human. J. Neurotrauma; 24: 354 -366.

-147. Xiang Y, Johnson EA, Zhang C, Huang G, Hayes RL, Wang KKW, Svetlov SI. (2006) Generation of aberrant forms of DFF40 concurrent with caspase-3 activation during acute and chronic liver injury in rats.. Biochem. Biophys. Res. Commun. 350:457-462.

-148. Zhang, Z.Q., Ottens, A.K., Sadasivan, S., Kobeissy, F.H., Fang, T., Hayes, R.L., Wang, K.K.W. (2007) Calpain-mediated CRMP proteolysis in excitotoxic and traumatic brain injury. J. Neurotrauma 24(3) 460-472.

-150. Germano, A., Caffo, M., Angileri,F.F., Arcadi, F., Newcomb-Fernandez, J., Caruso, G., Meli, F., Pineda, J.A., Lewis, S.B., Wang, K.K.W., Bramanti, P., Costa, C., Hayes, R.L. (2007) NMDA receptor antagonist felbamate reduces behavioral deficits and blood-brain barrier permeability changes after experimental subarachnoid hemorrhage in the rat. J. Neurotrauma 24:732-744.

-151. Lewis SB, Velat GJ, Miralia L, Papa L, Aikman JM, Wolper RA, Firment CS, Liu MC, Pineda JA, Wang KK, Hayes RL. (2007) Alpha-II spectrin breakdown products in aneurysmal subarachnoid hemorrhage: a novel biomarker of proteolytic injury. J Neurosurg. 107:792-796.

-152. Liu, J., Liu, M.C., Wang, K.K.W. Physiological and Pathological Actions of Calpains in Glutamatergic Neurons. Sci. Signal. 1 (issue 23), tr3.

-153. Ottens AK, Golden EC, Bustamante L, Hayes RL, Denslow ND, Wang KKW. (2008) Proteolysis of multiple myelin basic protein isoforms after neurotrauma: characterization by mass spectrometry., J. Neurochem. 2007 104, 1404-1414.

-154. Cox CD, West EJ, Liu MC, Wang KK, Hayes RL, Lyeth BG.(2008) Dicyclomine, an m1 muscarinic antagonist, reduces biomarker levels, but not neuronal degeneration, in fluid percussion brain injury. J Neurotrauma. 2008 Nov;25(11):1355-1365.

-155. Liu, J., Liu, M.C., Wang, K.K.W. (2008) Calpain in the CNS: From synaptic function to neurotoxicity. Science Signal., 1,( Issue 14), re1.

-156 Kobeissy, F., Sadasivan, S., Zheng, Z., Gold, M.S. and Wang, K.K.W. (2008) Psychiatric research: psychoproteomics, degradomics and systems biology. Expert Review of Proteomics 5(2):293-314.

-157. Kobeissy, F.H., Larner, S.F., Sadasivan, S., Zhiqun Zheng, Z., Liu, M,.C., Oli, M.W., Robinson, G., Hayes, R.L. and Wang, K.K.W. (2008) Neuroproteomic and Systems Biology-Based Discovery of Protein Biomarkers for Traumatic Brain Injury and Clinical Validation (Review). Proteomics – Clinical Applications 2 (10-11): 1467-1483.

-158. Kobeissy, F.H., Warren, M., Ottens, A.K., Zhang, Z.Q., Liu, M.C., Gold, M.S., Wang, K.K.W. (2008) “Psychoproteomic Analysis of Rat Cortex Following Acute Methamphetamine Exposure” J. Proteome Research, 7(5):1971-1983. Received Editorial Comment.

-159. Sadasivan, S., Dunn W.A.Jr., Hayes,R.L. and Wang, K.K.W. (2008) Changes in autophagy proteins in a rat model of controlled cortical impact induced brain injury” Biochem. Biophys Res. Commun 373, (Issue 4, 5) 478-481.

-160. Papa, L., Robinson, G. M.W. Oli, M.W., Robicsek, S.A., Gabrielli, A.   , Robertson, C. S., Wang, K.K.W. Hayes, R.L. (2008) Use of Biomarkers for Diagnosis and Management of Traumatic Brain Injury Patients. Expert Opin. Med. Diagnostics, (2008) 2(8):1-9

-161. Yao, C.P., Williams, A.J., Lu, M., Chen, R., Ottens, A.K., Wang, K.K.W., Hayes, R.L., Tortella, F.C. Dave, J. (2008) Detection of protein biomarkers using high-throughput immunoblotting following focal ischemic or penetrating ballistic-like brain injuries in rats. Brain Injury, 22 (10): 723-732.

-162. Svetlov, S.I., Larner, S.F., Kirk, D.R., Atkinson, J.P., Hayes, R.L., Wang, K.K.W. (2009) Biomarkers of Blast-Induced Neurotrauma: Profiling Molecular and Cellular Mechanisms of Blast Brain Injury. J. Neurotrauma 26, 1-9.

-163. Atkinson, J.P., Faure, J.M., Divitotawela, N.P., Kirk, D.R., Gutierrez, H.M., Svetlov, S.I., Wang, K.K.W., R. L. Hayes, Rautenstrauch, R. (2009) An innovative wave generation device and improved experimental protocol for conducting blast injury research. P127, 26th National Neurotrauma Symposium, July 27-30, Orlando, FL.

-164. Weiss, E.S., Wang, K.K.W., Allen, J.G., Blue, M.E., Nwakanma, L.U., Liu, M.C., Lange, M.S., Berrong, J., Wilson, M.A., Gott,V.L., Troncoso, J.C., Hayes, R.L., Johnston, M.V., and Baumgartner, W.A. (2009) αII-spectrin Breakdown Products Serve as Novel Markers of Brain Injury Severity in a Canine Model of Hypothermic Circulatory Arrest. Annals of Thoracic Surgery. 88, 543-550.

-165. Zhang, Z.Q., Majava, V., Greffier, A., Hayes, R.L., Kursula , P., Wang K.K.W. (2009) CRMP-2 is a calmodulin-binding protein. Cell. Mol. Life Sci. Feb;66(3):526-36.

-166. Brophy, G.M., Pineda, J.A., Pap, L., Lewis, S.B., Valadka, A.B., Hannay, H.J., Heaton, S.C., Demery, J., Liu, M.C., Aikman, J.M., Akle, V., Tepas, J.J. III, Wang, K.K.W., Robertson, C.S., Hayes, R.L. (2009) αII-Spectrin Breakdown Product Cerebrospinal Fluid Kinetics Suggest Differences in Cellular Injury Mechanisms after Severe Traumatic Brain Injury. J. Neurotrauma 2009 Apr;26(4):471-479.

-167. Miracle, A., Denslow, N.D., Kroll, K.J., Liu, M.C., Wang, K.K.W. (2009) Spillway-induced salmon head injury triggers proteolytic degradation of brain αII-spectrin similar to mammalian traumatic brain injury: Development of a biomarker assay. PLoS One 4(2) e4491.

-168. McGinn, M.J., Brian J. Kelley, B.J.,, Akinyi, L., , Oli, M.W.,, Liu,, M.C., , Hayes, R.L., Wang, K.K.W., Povlishock, J.T. (2009) Biochemical, structural and biomarker evidence for calpain-mediated cytoskeletal change following diffuse brain injury uncomplicated by contusion. J. Neuropathology & Experimental Neurology, J Neuropathol Exp Neurol. 68(3):241-249.

-169. Gold, M.S.*, Kobeissy, F H.*, Wang, K.K.W.*, Merlo, L.J., , Bruijnzeel, A.W., Krasnova, I.N., Cadet, J.L., (2009) Methamphetamine- and Trauma-Induced Brain Injuries: Comparative Cellular and Molecular Neurobiological Substrates. Biol. Psychiatry, Jul 15;66(2):118-27 (*equal contribution).

-170. Berger, R.P., Hayes R.L., Wang, K.K.W., Kochanek, P. (2009) Using Serum Biomarkers to Diagnose, Assess, Treat and Predict Outcome after Pediatric TBI. IN Geonimcs and Proteomics. (Eds. Anderson, Yates), Chapter 3, pp 36-53.

-171. Fuller, B.F., Gold, M.S., Wang, K.K.W., Ottens, A.K. (2010) Effects of Environmental Tobacco Smoke on Adult Rat Brain Biochemistry. J. Mol. Neurosci. May;41(1):165-71.

-172. Papa, L., Oli, M., Akinyi, L., Liu M.C., Zheng, W.R., Pineda, J., Kobeissy, F., Tepas, J., Robinson, G., Robicsek, S., Gabrielli, A., Heaton, S., Demery, J., Brophy, G., Layon, J., Robertson, C.S., Hayes, R., Wang, K.K.W. (2010) UCH-L1 is a novel biomarker in humans for severe traumatic brain injury. Critical Care Medicine 38, 138-144.

-173. Yao, C., Williams, A.J., Ottens, A.K., Lu, M., Liu, M.C., Hayes, R.L. Wang, K.K.W., Tortella, F.C., Dave, J.R. (2009) p43/EMAP-II: a potential biomarker for discriminating traumatic versus ischemic brain injury. J. Neurotrauma. 26(8):1295-305.

-174. Liu, M.C., Zheng, Akinyi, L., Oli, M.W., W.R, Larner, S.F., Kobeissy, F., Papa, L. Lu, X.-C., Dave, J.R., Tortella, F.C., Hayes, R.L. and Wang, K.K.W. (2010) Ubiquitin-C-Terminal Hydrolase as a Novel Biomarker for stroke and Traumatic Brain Injury in Rats. Eur. J. Neurosci. 31, 722–732.

-175. Zhang Z, Larner S, Liu MC, Zheng W, Hayes RL, Wang KKW. (2009) Multiple αII-spectrin Breakdown Products Distinguish Calpain and Caspase Dominated Necrotic and Apoptotic Cell Death Pathways. Apoptosis,  2009 Nov;14(11):1289-98.

-176. Svetlov, S.I., Prima, V., Kirk, D.R., Gutierrez, H., Curley, K.C., Hayes, R.L., and Wang, K.K.W. (2010). Morphologic and biochemical characterization of brain injury in a model of controlled blast overpressure exposure. Journal of Trauma 69(4):795-804.

-177. Prima, V. Wang, A., Gabriel Molina, G., Wang, K.K.W. Svetlov, S.I. V. (2011) Inhibition of LPS toxicity by hepatic argininosuccinate synthase (ASS): novel roles for ASS in innate immune responses to bacterial infection. Innate Immunity, 2011 Sep;11(9):1180-8.

-178. Sadasivan, S., Zhang, Z., Larner, S.F., Liu, M.C., Zheng, W., Kobeissy, F.H., Hayes, R.L., Wang, K.K.W. (2010) Acute NMDA toxicity in cultured rat cerebellar granule neurons is accompanied by autophagy induction and late onset autophagic cell death phenotype. BMC Neuroscience 18;11:21.

-179. Mondello, S., Robicsek, S.A., Gabrielli,A., Tepas, J., Robinson, C., Buki, A.,J. Mo, J., Scharf, D., Akinyi, L., Wang, K.K.W., Hayes, R.L. (2010) αII-Spectrin Breakdown Products (SBDPs): Diagnosis and Outcome in Severe Traumatic Brain Injury Patients; J. Neurotrauma 27(7):1203-1213.

-180. Ottens AK, Bustamante L, Golden EC, Yao C, Hayes RL, Wang KKW, Tortella FC, Dave JR. (2010) Neuroproteomics: A Biochemical Means to Discriminate the Extent and Modality of Brain Injury. J Neurotrauma. 27(10):1837-52

-181. Cassar SCTovcimak AERustay NREllis TAHooker BAWitte DGLi JBuck WRScharf DMuller UJeromin AWang KKWaring JF. Comparing Levels of Biochemical Biomarkers in CSF from Cannulated and Non-cannulated Rats. J Neurosci Methods. 192(2):249-53

-182. Liu, M.C., Kobeissy, F.H., Zheng, W.R, Zhang, Z.Q., Hayes, R.L., and Wang, K.K.W. (2011) Dual Vulnerability Of Tau To Calpain And Caspase-3 Proteolysis Under Neurotoxic And Neurodegenerative Conditions. ASN Neuro 2011 Feb 16;3(1):e00051.

-183. Martinez JA, Zhang Z, Svetlov SI, Hayes RL, Wang KKW, Larner SF. (2010) Calpain and caspase processing of caspase-12 contribute to the ER stress-induced cell death pathway in differentiated PC12 cells. Apoptosis. 2010 15(12):1480-93.

-184. Brophy, G.M.,, Mondello, S., , Papa, L,, Robicsek, S., Gabrielli, A., Tepas, J., , Buki, A., Claudia Robertson, C.S., Hayes, R.L., Wang, K.K.W. (2011) Biokinetic analysis of ubiquitin c-terminal hydrolase-L1 (UCH-L1) in severe traumatic brain injury patient biofluids. J. Neurotrauma 2011 Jun;28(6):861-70. Epub 2011 Apr 8

-185. Berger, R., Houle, J.-F., Hayes, R.L., Wang, K.K.W., Mondello, S., Bell, M. (2011) Translating Biomarker Research to Clinical Care: Applications and Issues for Rehabilomics. (review) 2011 Jun;3(6 Suppl):S31-8.

-186. Kobeissy, F.H., Guingab-Cagmat,J.D., Razafsha, M. , O’steen, L., Zhang, Z., Hayes, R.L., Chiu, W.-T., Wang, K.K. Leveraging Biomarker Platforms and Systems Biology for Rehabilomics and Biologics Effectiveness Research. Clinical Reviews: Current Concepts. PM&R 2011 . Jun;3(6 Suppl):S139-47.

-187. Mondello, S., Jeromin, A., Streeter, J., Hayes, R.L., Wang, K.K.W. (2011) Blood-based diagnostics of traumatic brain injuries. Expert Rev. Mol.. Diagn. 2011 Jan;11(1):65-78.

-188. Wang, A., Molina, G., Prima, V., Wang, K.K.W (2011) Anti-LPS Test Strip for the Detection of Food Contaminated with Salmonella and E. coli J Microbial Biochem Technol 2011, 3: Journal of Microbial & Biochemical Technology

-189. Kochanek , P.M., Bramlett, H., Dietrich, W.D., Dixon, C.E., Hayes, R.L., Povlishock J., Tortella, F.C., Wang, K.K. (2011) A novel multi-center pre-clinical drug screening and biomarker consortium for experimental traumatic brain injury: Operation Brain Trauma Therapy (Review). J. Trauma. Injury Infection & Critical Care: July 2011 – Volume 71 – Issue 1 – pp S15-S24.

-190. Guingab-Cagmat JD, Stevens SM Jr, Ratliff MV, Zhang Z, Gold MS, Anagli J, Wang KK, Kobeissy FH. Identification of tyrosine nitration in UCH-L1 and GAPDH. Electrophoresis. 2011 Jun;32(13):1692-705.

-191. Mondello,S. ,Akinyi, L.,Buki,A., Robicsek, S., Gabrielli, A., Tepas, J., Papa, L., Brophy, G., Tortella, F., Hayes,R.L., Wang, K.K.W. (2012) Clinical utility of serum levels of ubiquitin c-terminal hydrolase as a biomarker for severe traumatic brain injury. Neurosurgery, 70(3), 666-675. PMID: 21937927

-192. Ehrenreich, H., Kästner, A., , Weissenborn, K., , Streeter, J., Sperling, S., Wang, K.W., Worthmann, H., Hayes, R.L., von Ahsen, N., Kastrup, A., Andreas Jeromin, A., Herrmann, M. (2011) Circulating damage marker profiles support a neuroprotective effect of erythropoietin in ischemic stroke patients. Mol. Med. 17(11-12):1306-10.

-193. Berger, R.P., Hayes, R.L., Richichi, R., Wang, K.K.W. (2011) Serum concentrations of ubiquitin C-terminal hydrolase-L1 and αII-spectrin breakdown product 145 kDa correlate with outcome after pediatric TBI J. Neurotrauma 29:162–167.

-194. Arnaoutakis GJ, George TJ, Wang KK, Wilson MA, Allen JG, Robinson CW, Haggerty KA, Weiss ES, Blue ME, Talbot CC Jr, Troncoso JC, Johnston MV, Baumgartner WA.(2011) Serum levels of neuron-specific ubiquitin carboxyl-terminal hydrolase-L1 predict brain injury in a canine model of hypothermic circulatory arrest. J Thorac Cardiovasc Surg. 2011 Oct;142(4):902-910.e1.

-195. Zhang, Z., Mondello, S., Kobeissy, F.H., Rubenstein, R., Streeter, J., Hayes, R.L., Wang, K.K.W. (2011) Protein biomarkers for traumatic and ischemic brain injury: from Bench to Bedside Transl Stroke Res. (review) 2:455–462

-196. Mondello S, Papa L, Buki A, Bullock MR, Czeiter E, Tortella FC, Wang KK, Hayes RL. (2011) Neuronal and glial markers are differently associated with computed tomography findings and outcome in patients with severe traumatic brain injury: a case control study. Crit Care. 2011 Jun 24;15(3):R156.

-197. Svetlov, S.I., Prima, V., Kirk, D.R., Gutierrez, H., Curley K.C., Hayes, R.L., Wang, K.K.W. (2011) Neuroglial and systemic mechanisms of pathological responses to primary blast overpressure (OP) compared to ‘composite’ blast accompanied by head acceleration in rats. NATO Research and Technology Organisation; RTO-MP-HFM-207; 37-1 – 37-10.

-198. Papa, L. Lewis, L., Falk, J., Silvestri, S., Giordano, P., Brophy, G.M., Demery, J., Dixit, N.K., Ferguson, I., Liu, M.C., Mo., J., Akinyi, L., Schmid, K., Robertson, C.S., Mondello, S., Tortella, F.C., Hayes, R.L., Wang, K.K.W. (2012) Serum levels of ubiquitin C-terminal hydrolase (UCH-L1) distinguish mild traumatic brain injury from trauma controls and are elevated in mild and moderate tbi patients with intracranial lesions. J Trauma. 72: 1335–1344. PMID: 22673263

-199. Papa, L. Lewis, L., Falk, J., Zhang, Z., Silvestri, S., Giordano, P., Brophy, G.M., Demery, J., Dixit, N.K., Ferguson, I., Liu, M.C., Mo., J., Akinyi, L., Schmid, K., Robertson, C.S., Mondello, S., Tortella, F.C., Hayes, R.L., Wang, K.K.W. (2012) Elevated levels of serum glial fibrillary acidic protein breakdown products in mild and moderate traumatic brain injury are associated with intracranial lesions and neurosurgical intervention. Annals of Emergency Medicine 59(6):471-83. PMID: 22071014

-200. Ma, W., Han, W., Greer, P.A., Tuder, R.M., Wang, K.K.W., Su, Y. (2012) Calpain is a Novel Target in Pulmonary Vascular Remodeling of Pulmonary Hypertension. J. Clin. Invest. 121(11):4548-66. PMID: 22005303

-201. Mondello, S., Jeromin, A., Buki, A., Bullock, R., Czeiter, E., Kovacs, N., Barzo, P., Schmid, K., Tortella, F.,Wang, K.K., Hayes, R.L. (2012) Glial Neuronal Ratio (GNR): a Novel Index for Differentiating Injury Type in Patients with Severe Traumatic Brain Injury. J. Neurotrauma. 29:1096–1104.

-202. Svetlov, S.I., Prima, V., Glushakova, O., Svetlov, A., Kirk, D., Gutierrez, H., Serebruany, V., Curley, K., Wang, K.K.W., Hayes, R.L. (2012) Neuro-glial and systemic mechanisms of pathological responses in rat models of primary blast overpressure compared to composite blast. Frontier in Neurotrauma, Front Neurol. 2012;3:15.. PMID: 22403567

-203. Czeiter E, Mondello S, Kovacs N, Sandor J, Gabrielli A, Schmid K, Tortella FC, Wang KK, Hayes RL, Barzo P, Ezer E, Doczi T, Buki A (2012). Brain injury biomarkers may improve the predictive power of the IMPACT outcome calculator. J Neurotrauma. 2012 Jun 10;29(9):1770-8.

-204. Rice, D., Wang, K.KW., Robicsek, S. (2012) Biomarkers in Geriatric Traumatic Brain Injury. Current Translational Geriatrics and Experimental Gerontology Reports 1:129–134

-205. Mak, C.H.K., Wong, S.K.H., Wong, G.K., Ng, S., Wang, K.K.W., Lam P.K., Poon, W.S. (2012) Traumatic Brain Injury in the Elderly: Is it as Bad as we Think? Current Translational Geriatrics and Experimental Gerontology Reports 1: 171-178.

-206. Mondello S, Gabrielli A, Catani S, D’Ippolito M, Jeromin A, Ciaramella A, Bossù P, Schmid K, Tortella F, Wang KK, Hayes RL, Formisano R. Increased levels of serum MAP-2 at 6-months correlate with improved outcome in survivors of severe traumatic brain injury. Brain Inj. 2012 Jul 13. 2012;26(13-14):1629-35. PMID 22794497.

-207. Guingab J., Newsom, K., Vakulenko, A., Cagmat, E., Kobeissy, F.K., Zoltewicz, S., Wang, K.K.W. Anagli, J. (2012) An in vitro mass spectrometry-based proteomic analysis and absolute quantification of neuronal-glial injury biomarkers in cell culture system, ELECTROPHORESIS. 2012 Dec;33(24):3786-97 -208.

-208. Wang, K.K.W., Zoltewicz, S., Chiu, A., Zhang, Z., Rubenstein, R. (2012) Release of full-length PrPC from cultured neurons following neurotoxic challenges. Frontiers in Neurotrauma, Volume 3 Article 147; 1-9

-209. Cai Y, Zhu HX, Li JM, Luo XG, Patrylo PR, Rose GM, Streeter J, Hayes R, Wang KK, Yan XX, Jeromin A. Age-related intraneuronal elevation of αII-spectrin breakdown product SBDP120 in rodent forebrain accelerates in 3×Tg-AD mice. PLoS One. 2012 ;7(6):e37599. doi: 10.1371/journal.pone.0037599. Epub 2012 Jun 18.

-210. Boutté AM, Yao C, Kobeissy F, May Lu XC, Zhang Z, Wang KK, Schmid K, Tortella FC, Dave JR. (2012) Proteomic analysis and brain-specific systems biology in a rodent model of penetrating ballistic-like brain injury. Electrophoresis. 2012 Dec;33(24):3693-704.

-211. Zoltewicz, J.S. , Mondello, S. , Yang, B., , Newsom, K.J., , Kobeissy, F., , Yao, C.,, Xi-Chun Lu, M. , R. Dave, J.R., Shear, D.A.,, Kara Schmid, K., , Virginia Rivera, V., , Cram, T.,, Seaney, J., Zhiqun Zhang, Z., Wang, K.K.W., Hayes, R.L. and Tortella, F.C. Biomarkers Track Damage Following Graded Injury Severity in a Rat Model of Penetrating Brain Injury. J. Neurotrauma in press. (2013) 30(13):1161-9.

-212. Yokobori, S., Zhiqun Zhang, Z., Moghieb, A., Mondello, S., , Gajavelli, S., Dietrich, W.D., Bramlett, H., Hayes, R.L. Wang M. , Wang, K.K.W., Bullock, M.R. Biomarkers for spinal cord injury. (2013) World Neurosurgery, 2013 S1878-8750(13)00459-2. E-published

-213. Lam PK, Lo AW, Wang KK, Lau HC, Leung KK, Li KT, Lai PB, Poon WS. (2013) Transplantation of mesenchymal stem cells to the brain by topical application in an experimental traumatic brain injury model.J Clin Neurosci. 2013 Feb;20(2):306-9

-214. Tümer, N., Svetlov, S., Whiddenh, M., Kirichenko, N., Prima, V., Erdos, B., Sherman, A., Kobeissy, F., Yezierski, R., Vierck, C., Wang, K.K.W. (2013) Blast brain injury elevates oxidative stress in the hypothalamus and catecholamine biosynthesis in the rat adrenal medulla. Neurosci. Lett. 544:62-67.

-215. Kobeissy, F., Mondello, S., Prima, V., Yassin, W., Tumer, N. and Svetlov, S., Wang, K.K. Assessing Neuro-Systemic & Behavioral Components in the Pathophysiology of Blast-Related Brain Injury. Frontier in Neurotrauma in press.

-216. Blum K., Olive, F., Wang, K.K.W., Macelo, F., Borsten, J., Giordano, J., Hauser, M., Gold, M.S. Hypothesizing that designer drugs containing Cathinones (“Bath Salts”) have profound neuro-inflammatory effects and dangerous neurotoxic response following human consumption. Medical Hypothesis 2013, 81(3):450-5.

-217. Cooke, P.S., Nanjappa, M.K., Yang, Z., Wang, K.K.W. (2013) Therapeutic effects of progesterone and its metabolites in traumatic brain injury may involve non-classical signaling mechanisms. Frontiers in Neuroscience. (Review) Volume 7 | Article 108

-218. Tate, C., Wang, K.K*., Eonta, S., ; Naval Medical Research Center,, Zhang, Y., Carr, W.;, Tortella, F., Hayes, R., Kamimori, G. (2013) Serum Brain Biomarker Level, Neurocognitive Performance and Self-reported Symptom Changes in Soldiers Repeatedly Exposed to Low-Level Blast: A Breacher Pilot Study. (* corresponding author). Journal of Neurotrauma: 30: 1–11.

-219. Yokobori S, Bullock R, Gajavelli S, Burks S, Mondello S, Mo J, Wang KK, Hayes RL, Bramlett H, Dietrich D. Preoperative-induced mild hypothermia attenuates neuronal damage in a rat subdural hematoma model. Acta Neurochir Suppl. 2013;118:77-81.

-220. Diaz-Arrastia R, Wang KK, Papa L, Sorani MD, Yue JK, Puccio AM, McMahon PJ, Inoue T, Yuh EL, Lingsma H, Maas A, Valadka A, Okonkwo DO, Manley GT M D Ph D, Casey SS, Cheong M, Cooper SR, Dams-O’Connor K, Gordon W, Hricik AJ, Menon D, Mukherjee P, Schnyer DM, Sinha TK, Vassar MJ. Acute biomarkers of traumatic brain injury: Relationship between plasma levels of ubiquitin C-terminal hydrolase-L1 (UCH-L1) and glial fibrillary acidic protein (GFAP). J Neurotrauma. Jan 1;31(1):19-25

-221. Moghieb , A., Mangaonkar, M., Wang, K.K.W. (2013) Mass Spectrometry Based Translational Neuroinjury Proteomics. Translational Proteomics. 1: 65-73 (2013).

-222. Zhang Z, Zoltewicz JS, Mondello S, Newsom KJ, Yang Z, Yang B, Kobeissy F, Guingab J, Glushakova O2, Robicsek S, Heaton S, Buki A, Hannay J,Gold MS, Rubenstein R, Lu XC, Dave JR, Schmid K, Tortella F, Robertson CS, Wang KK. (2014) Human Traumatic Brain Injury Induces Autoantibody Response against Glial Fibrillary Acidic Protein and Its Breakdown Products. PLoS One. 2014 Mar 25;9(3):e92698

-223. -Kobeissy, F.H., Gulbakan, B., Alawieh, A., , Karam, P., , Zhang, Z., Guingab-Cagmat, J.D., , Stefania Mondello, S., , Tan, W., Anagli, J., Wang, K.K.W. (2014) Post-genomics nanotechnology is gaining momentum: Nanoproteomics and applications in life sciences. OMICS. 2014 Feb;18(2):111-31.

-224. Kobeissy, F. Tarek H, Mouhieddine, T.H., , Nokkari A., , Itani, M., Mouhieddine, M. , Zhiqun Zhang, Z., Zhu, R., PhD; and Gold M.S., Wang, K.K.W. (2014) Recent Updates of Drug Abuse Neuroproteomics Studies: Cocaine, Methamphetamine and MDMA. Translational Proteomics 2014. In press.

-225 Yang, Z., Lin, F., Robertson, C.S. Wang, K.K.W. (2014) Dual vulnerability of TDP-43 to calpain and caspase-3 proteolysis following neurotoxic conditions and Traumatic Brain Injury. J. Cereb. Blood Flow Metabol. JCBFM-0715-13 in press.

-226. Schober, M., Requena, DF., Davis, FJ, Ryan Metzger,, R, Bennett, KD, Morita, D, Niedzwecki, C, MD; Yang, Z, Wang, K.K.W. (2014) AlphaII Spectrin Breakdown Products in Immature Sprague Dawley Rat Hippocampus and Cortex after Traumatic Brain Injury. Brain Research in press.

 

Manuscripts

Toklu H.Z., Yang, Z., Oktay, S., Kirichenko, N., Metheny, M., Muller-Delp J., Sakarya, Y., Stran, K., LLinas, K., Scarpace, P.J., Wang, KKW, Tümer, N. (2014) Overpressure blast injury-induced oxidative stress and neuroinflammation responses in rat frontal cortex and cerebellum. Submitted.

Firas H Kobeissy 1, Ming Cheng Liu1, Zhihui Yang2, Wen Rong Zheng, Zhiqun Zhang1,   Ronald L. Hayes2 and Kevin K.W. Wang2 ,¥ Dual vulnerability of Dendritic protein MAP2 to calpain vs. Caspase-3 Proteolysis during different neural injury paradigms and biomarker implication. Submitted.

Andrew Maas, MD, PhD ; David Menon, MD, PhD; Ewout Steyerberg, PhD; Giuseppe Citerio, MD; Fiona Lecky, MD, PhD5; Geoffrey Manley, MD, PhD; Sean Hill, PhD; Valerie Legrand; Annina Sorgner; and the CENTER-TBI participants and investigators* (Kevin K.W. Wang*) (2014) Study Protocol (Short version) for Collaborative European NeuroTrauma Effectiveness research in TBI (CENTER-TBI): a prospective longitudinal observational study. Neurosurgery. Submitted.

Linda Papa, Salvatore Silvestri, Gretchen M. Brophy, Philip Giordano, Jay L. Falk; Carolina F. Braga, Ciara N. Tan, N. J. Ameli; Jason A. Demery,; Neha K. Dixit,; Matthew E. Mendes,; Ronald L. Hayes,; Kevin K. W. Wang,; Claudia S. Robertson, GFAP Out-performs S100β In Detecting Traumatic Intracranial Lesions On CT In Trauma Patients With Mild Traumatic Brain Injury And Those With Extracranial Lesions J. Neurotrauma E-Pub 10-2014.

Book Chapters

  1. Wang, K.K.W. (1996) Intracellular Ca2+-binding proteins.(review) In Principles of Medical Biology (Eds. E.E. Bittar and N. Bittar), JAI Press Inc., Greenwich, Connecticut, pp. 253-270.
  2. Wang, K.K.W., Posner, A., Raser, K.J., Buroker-Kilgore, M., Probert, A.W., Marcoux, F.W., Hays, S.J., Lunney, E. and Hajimohammadreza, I., Yuen, P.-w. (1996) Α-mercaptoacrylic acid derivatives as novel selective calpain inhibitors. In: Intracellular Protein Catabolism (Ed. K. Suzuki, J.S. Bond), Plenum Publishing. 95-102.
  3. Wang K.K.W. and Yuen, P.-w. (1999) Calpain Substrates, Assay Methods, regulation and Inhibitory agents. In Calpain: Pharmacology and Toxicology of a Calcium-dependent Cellular Protease (Eds. K. Wang, P. Yuen), Taylor and Francis, Chapter 5, pp 77-101.
  4. Wang, K.K.W. (1999) Detection of proteolytic enzymes using protein substrates. In Proteolytic Enzymes -Tools and Targets (Springer Lab Manual) (Sterchi, E.E., Stocker, W. Eds.) Springer-Verlag, Heidelberg, Chapter 4, pp. 49-62.
  5. McGinnis, K.M., Nath, R., Wang, K.K.W., Posmantur, R. (1999) Proteases and Proteolysis in Neuronal Degeneration. In “Recent Research Developments in Neurochemistry” (Pandalai, S.G. Ed.) , Research Signpost, India, Vol. 2, 207-216.
  6. Wang, K.K.W., Yuen, P.-w., Lee, K.S. (1999) Calpain in excitotoxicity, cerebral ischemia and neuronal apoptosis In Calpain: Pharmacology and Toxicology of a Calcium-dependent Cellular Protease (Eds. K. Wang, P. Yuen), Taylor and Francis, Chapter 9, pp 179-209.
  7. Zhang, Z., Kobeissy, F.H. Ottens, A.K., Martínez, J.A. and Wang, K.K.W. (2009) Calmodulin Binding Proteome in the Brain –Ch. 12 “Neuroproteomics Methods”. Methods in Molecular Biology (Series) (Eds. K.K.Wang, A.K. Ottens); Humana Press., Dordrech; 12, 566:181-192.
  8. Kobeissy, F.H. Zhang, Z., Sadasivan, S., Mark S. Gold, M.S. and Wang, K.K.W. (2009) Methods in Drug Abuse Neuroproteomics: Methamphetamine Psychoproteome, “Neuroproteomics Methods”. Methods in Molecular Biology (Series); (Eds. K.K.Wang, A.K. Ottens); Humana Press., Dordrech; 15, 566:217-228.
  9. Wang, K.K.W. (2002) Calpain and caspase in ischemic and traumatic brain injury. In New Concepts in Cerebral Ischemia. (Ed. Rick Lin) CRC press, Chapter 8 , 181-200.
  10. Wang, K.K.W. (2002) Therapeutic approaches with protease inhibitors in neurodegenerative and neurological diseases In: Role of Protease in the Pathology of Neurodegenerative Disease (N. Banik, A. Lajtha and Smith eds.), Kluwer Academic/Plenum Publishers, New York, Chapter 13. pp. 250-279.
  11. Wang, K.K.W. (2003) Limiting Apoptosis in Neurodegeneration In: Handbook of Experimental Pharmacology; Volume – “CNS Neuroprotection” (F.W. Marcoux; D.W. Choi, Eds.) Springer-Verlag, Berlin, pp 37-64. (Chapter 2).
  12. Chen,S.S, Haskins, W.E., Zhang, ZQ, Denslow, N., A., Hayes, R.L. Wang, K.K.W. , Ottens, AK, (2007) Bioinformatics for Traumatic Brain Injury: Proteomic Data Mining In “Data Mining in Biomedicine” (Ed. Panos Pardalos , Boginski, V.L., Vazacopoulos, A.   Springer, pp. 1-26.
  13. Zhang, Z.Q., Kammerdiner, A.R.; Busygin, S.P., Ottens, A.K.; Larner, S.F.; Kobeissy, F.H.; Pardalos, P.M.; Hayes, R.L. Wang, K.K.W. (2007) Application of the Data Mining Techniques to the Systems Biology of Neuritogenesis. Optimization Methods and Software, Volume 22, pages 215 – 224
  14. Larner, S.F., Hayes, R.L., Wang, K.K.W. (2009) Proteolytic Mechanisms of Cell Death in the Central Nervous System. In Handbook of Neurochemistry and Molecular Neurobiology. ( Abel Lajtha) Vol. 24: Brain and Spinal Cord Trauma 240-279.
  15. Oli, M.W., Hayes, R., L., Gillian Robinson, G., Wang, K.K.W. (2010) Traumatic Brain Injury Biomarkers: From Pipeline to Assay Development –Neuroproteomics Methods”. Methods in Molecular Biology (Series) (Eds. K.K.Wang, A.K. Ottens); Humana Press., Ch. 19, 566: 293-302.
  16. Hayes, R.L., Robinson, G., Muller, U., Wang, K.K.W. (2009) Translation of Neurological Biomarkers to Clinically Relevant Platforms, Ch. 20. Neuroproteomics Methods”. Methods in Molecular Biology (Series); (Eds. K.K. Wang, A.K. Ottens); Humana Press., Ch. 20, 566: 303-314.
  17. Guingab, J.D., Kobeissy, F.H., Ratliff, M., Zhang, Z., Wang, K.K.W. (2010) Neurogenomic And Neuroproteomic Approaches To Studying Neural Injury In “Essentials of Spinal Cord Injury.” (Eds.. Fehlings,. Vaccaro,. Boakye,. Rossignol,. Ditunno, and. Burns) Thieme Publishers.
  18. \
  19. Kobeissy, F.H., Sadasivan, Buchanan, M., Zhang, Z., Gold, M.S., Wang, K.K.W. (2010) Methods in Systems Biology of Experimental Methamphetamine Drug Abuse In “Systems Biology in Drug Discovery and Development (Qing Yan ed.)” Humana Press. . Chapter 15, pp. 303-316.
  20. Berger RP, Hayes R, Wang KK, Kochanek P (2010) Using serum biomarkers to diagnose, assess, treat and predict outcome after pediatric traumatic brain injury In New Frontiers in Pediatric Traumatic Brain Injury (Eds. Vicki A Anderson, PhD and Keith Owen Yeates) Cambridge University Press pp 36-53.
  21. Wang, K.K., Zhang, Z.Q., Kobeissy, F.H., Chiu, W.T. (2012) Utility of biomarkers for diagnosis and prognosis of traumatic brain injury IN Traumatic Brain & Spinal Cord Injury: Challenges & Developments (Eds. C. Morganti-Kossmann, R. Raghupathi & A. Maas) Cambridge University Press (31 July 2012)
  22. Anagli, J., Wang, K.K.W., Ono, Y., and Sorimachi, H. (2011) Calpains in health and disease. E-book on Proteases – Structure and Function (Ed. Klaudia Brix and Walter Stoecker)
  23. Mondello,S. Kobeissy F., Fingers, I., Zhiqun Zhang, Z., Ronald Hayes,R., Wang,K.K.W. Data Mining Strategies Applied in Brain Injury Models: Panos M Pardalos; Petros Xanthopoulos, Zervakis, Michalis (Eds.) Data Mining for Biomarker Discovery: (Springer) Feb, 2012 ISBN 978-1-4614-2106; http://www.springer.com/mathematics/applications/book/978-1-4614-2106
  24. Mondello S, Jeromin A, Kobeissy FH, Guingab-Cagmat JD, Zhiqun Z, Streeter J, Hayes RL, Wang KK. Novel Strategies for Discovery, Validation and FDA Approval of Biomarkers for Acute and Chronic Brain Injury Amit Agrawal (Ed). Brain Injury Book 2, (INTECH Publishing Group), ISBN 978-953-307-614-0.
  25. Guingab-Cagmat, J., Bauzo, R.M., , Bruijnzeel , A.W., Wang, K.K.W., Gold, M.S. and Kobeissy, F.H. (2012) Methods in Tobacco Abuse: Proteomic Changes Following Secondhand Smoke Exposure. Methods in Molecular Biology, 2012;829:329-48.
  26. Razafsha, M., Behforuzi, H., Azari, H., Zhang, Z., Wang, K.K., Kobeissy, FH and Gold, M.S. (2012) Qualitative Versus Quantitative Methods in Psychiatric Research In Methods in Molecular Biology 2012;829:49-62.
  27. Kobeissy, F.H., Mitzelfelt, J.D., Fishman ,I. Morgan, D., , Roger Gaskins, R., , Zhang, Z., , Gold , M.S. and Wang, K.K.W. (2012) Methods in Drug Abuse Models: Comparison of Different Models of Methamphetamine Paradigms. Methods in Molecular Biology 2012;829:269-78.
  28. Mondello, S., Hyaes, R.L., Wang, K.K.W. Utilities of TBI biomarkers in various clinical settings. Chapter 12 in (Ed. S. Hayes, R.L., Wang, K.K.W. Editors) (2012) “Biomarkers for Traumatic Brain Injury” (RSC Drug Discovery) Royal Society of Chemistry (30. June 2012) pp.
  29. Kobeissy, F.H., Gulbakan, B., Shukoor, M.I., Larner, S., Guingab-Cagmat, J.D., Zhang, Z., Anagli, J., Wang, K.K.W. Nanoproteomics: Advanced Nanotechnology Platforms in Protein Science, in press.
  30. Mondello, S., Wang, K.KW, Hayes, R.L. (2013) “Blood biomarkers for traumatic brain injury”, section:(Experimental Models and Methods). IN “Vascular Mechanisms in CNS Trauma” (eds. Lo, Lok, Ning, Whalen). In press.
  31. Wang, K.K.W., Zhang, Z., Moghied, M. Chapter 28. Biomarkers for CNS injury and regeneration IN: Neural Regeneration (ED. Kwok-Fai So, Xiao-Ming Xu) Goodman Campbell Brain & Spine.in press
  32. Mohammed Ibrahim Shukoor, Muhammad Nawaz Tahir, Thomas Schladt, Wolfgang Tremel, Zhiqun Zhang, Kevin K. Wang, and Firas H. Kobeissy Engineered Multifunctional Nanotools for Biological Applications. Steven A. Toms and Robert J. Weil (eds.), Nanoproteomics: Methods and Protocols, Methods in Molecular Biology, vol. 790, DOI 10.1007/978-1-61779-319-6_16, © Springer Science+Business Media, LLC 2011
  33. Ali Alawieh, Zahraa Sabra, Zhiqun Zhang, Firas Kobeissy and Kevin K.W.Wang. Chapter 1. Neuro-proteomics and Neuro-systems Biology in the Quest of TBI Biomarker Discovery. 17457 17 pp. Biomarkers of Brain Injury & Neurological Disorders (Editors: Wang, Zhang and Kobeissy) ISBN 9781482239829 CRC Press
  34. Angela Boutte, Firas Kobeissy, Kevin K.W. Wang, Zhiqun Zhang, Frank Tortella, Jitendra R Dave and Kara Schmid, Chapter 2 Protein Biomarkers in Traumatic Brain Injury: An Omics Approach., 14470 40 pp Biomarkers of Brain Injury & Neurological Disorders (Editors: Wang, Zhang and Kobeissy) ISBN 9781482239829 CRC Press
  35. Nagaraja S. Balakathiresan, Anuj Sharma, Raghavendar Chandran, Manish Bhomia, Zhiqun Zhang, Kevin K.W. Wang and Radha K Maheshwari, Chapter3, Molecular Mechanisms and Biomarker Perspective of MicroRNAs in Traumatic Brain Injury, 17627 67pp, Biomarkers of Brain Injury & Neurological Disorders (Editors: Wang, K.K., Zhang, Z. and Kobeissy, F.H.) 2013 ISBN 9781482239829 CRC Press
  36. Sadasivan S., Wang, K.K.W. and Zhang, Z., Chapter 4. Necrosis, apoptosis and autophagy in acute brain injury: The utilities of biomarkers. 6757 24 pp, Biomarkers of Brain Injury & Neurological Disorders (Editors: Wang, Zhang and Kobeissy) 2013 ISBN 9781482239829 CRC Press
  37. Zhang, Z., Moghieb, A. and Wang, K.K.W., Chapter 5, Acute, Subacute and chronic Biomarkers for CNS injury., 8487 27 pp, Biomarkers of Brain Injury & Neurological Disorders (Editors: Wang, K.K., Zhang, Z .and Kobeissy, F.H.) ISBN2013 9781482239829 CRC Press
  38. Papa, L., Ameli, N.J. , Waplinger, A., Zhang, Z. and Wang, K.K.W. Chapter 7 In: Protein Biomarkers for Mild Traumatic Brain Injury/ 6509 20 pp, Biomarkers of Brain Injury & Neurological Disorders (Editors: Wang, K.K., Zhang, Z. and Kobeissy, F.H.) ISBN2013 9781482239829 CRC Press
  39. Yokobori S.,, Hosein, K., Wang, M.Y., Gajavelli, S., Moghieb, A., Zhang,Z., Wang, K.K.W. Bullock, M.R. and Dietrich, W.D. (2014) Biomarkers in Spinal Cord Injury. In Biomarkers of Brain Injury & Neurological Disorders (Editors: K. Wang, Z. Zhang and F.H. Kobeissy) ISBN2013 9781482239829, CRC Press. Chapter 11, pp 340-354.
  40. Wang, K.K.W., Zhang, Z., Moghieb, A. (2015) Biomarkers for CNS Injury and Regeneration. Chapter 26 IN: (Ed. Xu, X.M., So, K.F. ) Neuroal Regeneration. Elseiver (New York).

Other Publications

-1. Larner, S.F., Wang, K.W., Oli, M.W., Robinson, G., Andrea Gabrielli, A., Robicsek, S.A., Robinson, C.S., Hayes, R.L. (2008) Biomarkers: The Future of Diagnosis and Therapy for Traumatic Brain Injury . International NeuroTrauma Letter, issue 02 (2008).

-2. Liu, J., Liu, M.C., Wang, K.K.W. Physiological and Pathological Actions of Calpains in Glutamatergic Neurons. Sci. Signal. 1 (issue 23), tr3 (June 10, 2008).

-3. Wang, K.K.W. , Ronald L. Hayes, Brain Injury Biomarkers and Their Utilities in Personalized Medicine Asia Pacific Biotech News (APBN) August 2011 Issue 26-29. (published 8/22/11).

-4. Hayes RL, Mondello S, Wang K.K. Glial fibrillary acidic protein: a promising biomarker in pediatric brain injury. Pediatr Crit Care Med. 2011 Sep;12(5):603-4.

SELECTED ABSTRACTS

Ferguson, I.. Lewis, L. Papa, L., Wang, K.K., Mondello, S., Hayes, R. 106 Neuronal Biomarkers May Require Age-Adjusted Norms Annals of Emergency Medicine – ANN EMERG MED 01/2011; 58(4). DOI:10.1016/j.annemergmed.

Papa, L. et al. Robicsek, S.A, Wang, K.K.W. (2012) Assessing Necrosis And Apoptosis Index Using CSF AlphaII-Spectrin Breakdown Product Levels In Severe TBI. National Neurotrauma Conference 2012 (Phoenix, July 22-25, 2012) Abstract.

Wang, K.K.W. (2010) Systems biology, protein and metabolomic biomarker approach to traumatic brain injury. ATTACCC Conference, 2010, St. Petersburg, FL. (Aug. 15-18, 2010), Talk Abs.

Robicsek, S.A., Papa, L., Heaton, S., Hannay, H.J., Gabrielli, A., Wang, K.K.W., Brophy, G.M., Schmalfuss, I., Mondello, S., Hayes, R., Robertson, C. (2012) Predicting poor 6-month outcome in severe TBI using the impact score and early CSF biomarkers. The 30th Annual National Neurotrauma Symposium, July 22–25, 2012, Phoenix, Arizona; Abs. B33.

Wang KK, Robicsek SA, Robertson CS, Brophy G, Gabrielli A, Hannay HJ, Heaton S, Hayes RL, Mondello S, Schmalfuss I, Papa L. (2012) Assessing a Necrosis and Apoptosis: Index Using CSF Alpha II-spectrin Breakdown Product Levels in Severe TBI. 30th National Neurotrauma Symposium (Phoenix, AZ. July 2012) Abstract.

Kochanek, P. Bramlett, H., Dietrich, W.D., Dixon, C.E., Mondell, S., Hayes, R.L., Povlishock J., Tortella, F.C., Zhang, Z., Wang, K.K. Cross model comparison of behavior, neuropathology, and acute serum biomarkers after controlled cortical impact, parasagittal fluid percussion, and penetrating ballistic-like brain injury: Results from Operation Brain Trauma Therapy. The 30th Annual National Neurotrauma Symposium, July 22–25, 2012, Phoenix, Arizona; Abs. B22.

PATENTS

Issued patents

Yuen P-w., Wang, K.K.W. (1996) Substituted α-mercaptoacrylic derivatives having calpain inhibitory activity. (US Patent # 5,554,767 (issued. Sept. 10, 1996)

Yuen P-w., Wang, K.K.W. (1997) Αlpha-substituted hydrazides having calpain inhibitory activity (US Patent # 5,679,680). (Issued Oct 21, 1997)

Melker, R.J., Hayes, R.L., Wang, K.K.W., Dennis, D.M. Application of Nanotechnology and Sensor Technologies for In-Vitro Diagnostics” US patent 7,052,854 issued 5-30-2006 (applc. no. #678506 filed Oct. 2, 2003).

Hayes, R.L. Wang, K.K.W., Pike, B.R., (2007) “Detection of Spectrin and Spectrin proteolytic cleavage products in assessing nerve cell damage” (US patent applic. #60/409.920 filed 9—11, 2003; conversion applic. 11/6/2008, US patent 7,291,710 issued Nov 6, 2007.

Hayes, R.L., Wang, K.K.W., Liu, M.C., Oli, M. (2008) “Neural proteins as biomarkers for traumatic brain injury” (US provisional applic. filed 4-15-2004 as 60/562.944; filed US conversion patent 4-15-2005 (Serial # 11/107,248) US Pre-Grant Pub US20050260654, US Patent 7,396,654 issued July 8, 2008.

Hayes, R.L., Wang, K.K.W., Liu, M.C., Oli, M. (2008) “Proteolytic biomarkers for traumatic injury to the nervous system”. (filed provisional 4-15-2005 as 60/562819; Conversion filed 4/15/2006 (Serial# 11/106,932) as US20050260697), US Patent 7,456,027 issued Nov. 25, 2008.

Svetlov, S., Hayes, R.L., Wang, K.K.W., (2009) UF533XTC1 Detection of Cannabinoid receptor biomarkers and uses thereof. Priority date 21.10.2004; Serial no. 11/738,159, filed April 20, 2007; ((WO/2006/047417) US Patent No, 7,611,858 (issued Nov. 3, 2009)

Wang, K.K.W., Hayes, R.L., Pike, B. (7-9-2009) Analyzing Nerve Cell Damage. Australian Patent 2003270509 (UF530XTAU) (issued 7-9-2009) (original filing 9-11-2003)

Wang, K.K.W., Hayes, R.L., Liu, M.C., Oli, M. (2009) “Neural proteins as biomarkers for nervous system injury and other neural disorders” Australian Standard Patent 11-12-2009 B2 (issued Nov. 12, 2009), original filing 4-15-2004.

Svetlov, S., Ottens, A.K., Wang, K.K.W., Hayes, R.L. Oli, M. “Biomarkers of liver injury.” US patent appl. No. 60668121(WP297394) filed 4-1-2005, pending pub # 20060246489; Conversion filed 3-21-2006;   –US Patent # 7,645,584 (issued Jan 12, 2010)

Hayes, R.L., Wang, K.K.W., Liu, M.C., Oli, M. (2008) “Neural proteins as biomarkers for traumatic brain injury” Japanese Patent Applic no. 2007-508545.issued

Svetlov, S., Hayes, R.L., Wang, K.K.W., (2009) Detection of Cannabinoid receptor biomarkers and uses there of. Priority date 21.10.2004; Serial no. 11/738,159, filed April 20, 2007; (WO/2006/047417) UF533XTC1, US Patent No, 7,611,858 (issued Nov. 3, 2009)

Wang, K.K.W., Hayes, R.L., Liu, M.C., Oli, M.K. (2009) “Neural proteins as biomarkers for nervous system injury and other neural disorders” original filing 4-15-2004, Australian Standard Patent 2,005,238,446 (issued Nov. 12, 2009).

Wang, K.K.W., Hayes, R.L., Liu, M.C., Oli, M.K. (2009) PROTEOLYTIC MARKERS AS DIAGNOSTIC BIOMARKERS FOR CANCER, ORGAN INJURY AND MUSCLE REHABILITATION/EXERCISE OVERTRAINING. Australian Standard Patent 2005245785 (issued April 7, 2011).

Dave, J.R., Yao, C., Williams, A.J., May, X.C., Tortella, F.C., Wang, K.K.W., Hayes, R.L. (2010) Endothelial Monocyte activating polypeptide II. Biomarker for use in Diagnosis of brain injury.   Sep/ 21, 2010 issued US Patent 7,799,536 B2.

Wang, K.K.W., Hayes, R.L., Liu, M.C., (2009) Proteolytic markers as diagnostic biomarkers for cancer, organ injury and muscle rehabilitation/exercise overtraining Australian Patent No. 2005245785

Svetlov, S., Ottens, A.K., Wang, K.K.W., Hayes, R.L. Oli, M. “Biomarkers of liver injury.” US patent appl. No. 60668121(WP297394) filed 4-1-2005, pending pub # 20060246489; Conversion filed 3-21-2006; –US Patent # 7,645,584 (issued Jan 12, 2010)

Wang, K.K.W., Hayes, R.L., Liu, M.C., Oli, M. (2008) “Neural proteins as biomarkers for traumatic brain injury” Japanese Patent Applic no. 2007-508545. Japanese Patent 2007-508545 issued Nov. 10, 2011.

Wang, K.K.W., Zhang, Z.Q., Liu, M.C., Hayes, RL., Dave, J. (2010) Micro-RNA, Autoantibodies and Protein Markers for Diagnosis of Neuronal Injury. Priority date 9-14, 2009; Filed Sept 14, 2010 PCT WO2011032155A2 (published 3-17-2011). US Patent Publication US20130022982 (published Jan 24, 2013).

Ottens A.K., Kobeissy, F.H., Wang, K.K.W., Hayes R.H., Zhang Z., Liu M.C., Oli M. Synaptotagmin and collapsin response mediator protein as biomarker for traumatic brain injury PCT(WO-2008-097618) A1 (US 8557526 B2 issued 10/15/2013)

Pending patent applications (PCT published)

Bian, Feng; Yuyang Ye; Yuyang; Lyer, Rathan; Wang, Kevin K.W. (2002) “Transgenic Mice That Overexpression of Transglutaminase 2 with Nerve Cell-Expression Promoter”. PCT# 020546 (US provisional patent application 60/583,415; United States Patent applic. 20060015959).

Wang, K.K.W., Zhang, Z.Q., (2011) Glial fibrillary acidic protein, autoantigens and autoantibodies thereto as Biomarkers of Neural Injury or neurological disorder or condition. PCT -WO2011160096A2 priority date june 17, 2011 (published 12-12-2011).